2013, Number 3
Farmacodermia by Amlodipine. A Case Report
Salcido-de Pablo PA, Urrutia-Guerrero JS, Valdés-Castañeda SL, Montiel-Estrada AP, Pérez-Zea A, Bourlon-Cuéllar R
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Language: Spanish
References: 5
Page: 327-330
PDF size: 376.26 Kb.
ABSTRACT
Background: Eighty years old female, with arterial hypertension in treatment with amlodipine, and sclerodermia. In November 2012 she presented disseminated dermatosis on arms, forearms, abdomen, and legs. It affected solar exposed zones, and was characterized by plaques of different sizes with erithematose base, elevated temperature, peeling, transudate, and meliceric crusting.Material and Methods: Information was taken from an 80 years old female, based on clinical features, laboratory, and pathology testing.
Results: Rheumatoid factor, antinuclear antibodies, antitopoisomerase, anticentromere, and acute phase reactants were negative. Dermatology associated skin lesions with the use of amlodipine, so we prescribed the suspension of the drug, topic steroid, and moisturizer with a good response.
Conclusions: Toxicodermas occur in 0.3% of all treatments and are a cause of medical consults in 5% of the times. Adverse reactions of amlodipine include allergic exanthema, cutaneous hyperpigmentation, annular granuloma, erythema multiform, and toxic epidermal necrolysis. Risk factors are: older than 60 years old, genetic predisposition, and preexisting illness. It is an allergic reaction, with immunologic and no immunologic factors associated. The diagnosis is clinical, and involves the effect of the interruption of the drug. The treatment is the interruption of the medication. Toxicodermas are an adverse reaction that occur frequently in the elderly, associated to polypharmacy and polypathology. It is important to document it because it affects quality of life and elevates morbidity and mortality.
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