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2012, Number 3

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Med Sur 2012; 19 (3)

Infección por H. pylori asociada a trombocitopenia idiopática, reporte de caso y revisión de la literatura

Manzano-Robleda MC, Toapanta-Yancapaxi LN, Motola-Kuba M, Aguilar N, De La Peña R, Lizardi-Cervera J
Full text How to cite this article

Language: Spanish
References: 6
Page: 176-179
PDF size: 65.21 Kb.


Key words:

H. pylori infection, Thrombocytopenia.

ABSTRACT

There are several reports that support the association of Helicobacter pylori (H. pylori) infection and hematologic disorders, including idiopatic trombocitopenic purpura (ITP). For these reason, the bacteria should be investigated and treated in patients with some of these disorders without any other explanation, for example, in patients with ITP and no improvement with corticosteroid and Danazol therapy, the additional eradication of H. pylori with immunosuppressive therapy improves the outcome than eradication therapy alone. In ITP patients, it has been reported an improvement of 50% in the platelet count after H. pylori eradication. Accordingly to this, it is recommended to diagnostic testing for H. pylori in ITP patients. Different platelet count outcomes have been reported depending on bacteria strain.


REFERENCES

  1. Malfertheiner P, Megraud F, O’Morain CA, Atherton J, Axon ATR, Bazzoli F, Gensini GF, et al. The European Helicobacter Study Group (EHSG). Management of Helicobacter pylori infectiondthe Maastricht IV/Florence Consensus Report. Gut 2012; 61: 646-64.

  2. Pellicano R, Franceschi F, Saracco G, Fagoonee S, Roccarina D, Gasbarrini A. Helicobacters and Extragastric Diseases. Journal compilation 2009. Blackwell Publishing Ltd, Helicobacter 14 (Suppl. 1): 58-68.

  3. Stasi R, Sarpatwari A, Segal JB, Osborn J, Evangelista ML, Cooper N, et al. Effects of eradication of Helicobacter pylori infection inpatients with immune thrombocytopenic purpura. A systematic review. Blood 2009; 113: 1231-40.

  4. Arnold DM, Bernotas A, Nazi I, Stasi R, Kuwana M, Liu Y, John G, et al. Platelet count response to H. pylori treatment in patients with immune thrombocytopenic purpura with and without H. pylori infection: a systematic review. Haematologica 2009; 94(6).

  5. Fujimura K, Kuwana M, Kurata Y, Imamura M, Harada H, Sakamaki H, et al. Is eradication therapy useful as the first line of treatment in Helicobacter pylori-positive idiopathic thrombocytopenic purpura? Analysis of 207 eradicated chronic ITP cases in Japan. Int J Hematol 2005; 81: 162-8.

  6. Emilia G, Luppi M, Zucchini P, Morselli M, Potenza L, Forghieri F, et al. Helicobacter pylori infection and chronic immune thrombocytopenic purpura: longterm results of bacterium eradication and association with bacterium virulence profiles. Blood 2007; 110: 3833-41.




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Med Sur. 2012;19