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ISSN 1405-1710 (Print)

2000, Number 1

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Rev Cent Dermatol Pascua 2000; 9 (1)

Open, comparative and prospective study between the combination betamethasone 0.25 mg/loratadine 5 mg tablets and malate of chlorpheniramine 8 mg pills of lingering liberation, in patient with moderate acute urticaria to severe

de Alba AL, Elizondo RA, Sánchez RP

Language: Spanish
References: 8
Page: 43-48
PDF size: 180.67 Kb.


ABSTRACT

This was an open, comparative and prospective study designed to compare the efficacy and safety of the combination of betamethasone 0.25 mg/loratadine 5 mg tablets with chlorpheniramine maleate 8 mg extended release tablets in the treatment of clinical manifestations of moderate to severe acute urticaria. Fifty-four patients were included within two centers, finishing 51; 24 in the betamethasone/loratadine group and 27 in the chlorpheniramine group. The dosage regimen for each group, was one tablet every twelve hours during five days. Efficacy was assessed on third and fifth days on the basis of decreased of the urticarial lesions, latency, decreased of the pruritus and the patient and physician’s global evaluation of improvement. Safety was assessed through a questionnaire and on the adverse effects report. The results confirm the effectiveness of both treatments for the initial management of acute urticaria, in which the shorter latency for the betamethasone/loratadine group provided a clinical advantadge over the chlorpheniramine treatment. The adverse events were similar for both groups.


REFERENCES

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