Carballo E, Roque A, Durán-Monterrosas LA, Kably AA

Language: Spanish
References: 10
Page: 329-333
PDF size: 385.77 Kb.

ABSTRACT

Background: Although age to conceive has been delayed in both males and females, male age is controversial as decisive for this purpose.
Objective: To describe the results of intrauterine insemination pregnancy according to the age of the man. To determine whether this variable modifies semen parameters. To analyze whether pregnancy outcomes are modified by sperm morphology.
Patients and methods: A descriptive, retrospective, longitudinal and analytical study. We analyzed 2,276 intrauterine insemination cycles performed in the Mexican Center for Fertility CEPAM from January 2000 to December 2012. We included only women under 35 years old without tubal occlusion. Semen parameters were evaluated after capacitation and the pregnancy rate by male age group and sperm morphology was analyzed. The results were analyzed with SPSS 20. Continuous variables were reported as means and their standard deviations and logistic regression univariate to determine the statistical significance. The categorical variables were evaluated in frequencies and percentages.
Results: 2,276 intrauterine insemination cycles were pooled according to the age of the male. The lower pregnancy rate was found in the group of men over 50 years. There was negative correlation between the increasing age with the total motile cell volume and morphology. There was only one pregnancy from a male over 50 years. When morphology was less than 4%, the pregnancy rate was significantly lower after 45 years; if it was more than 4% this effect was not observed.
Conclusion: Male age affects pregnancy outcomes in intrauterine insemination cycles, as long as the sperm morphology is altered.

REFERENCES

1. Kidd SA, Eskenazi B, Wyrobek AJ. Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril 2001;75:237-248.

2. Humm KC, Sakkas D. Role of increased male age in IVF and egg donation: is sperm DNA fragmentation responsible? Fertil Steril 2013;99:30-36.

3. Hassan MAM, Killick SR. Effect of male age on fertility: evidence for the decline in male fertility with increasing age. Fertil Steril 2003;79(Suppl 3):1520-1527.

4. Frattarelli JL, Miller KA, Miller BT, Elkind-Hirsch K, Scott RT. Male age negatively impacts embryo development and reproductive outcome in donor oocyte assisted reproductive technology cycles. Fertil Steril 2008;90:97- 103.

5. Karabinus DS, Gelety TJ. The impact of sperm morphology evaluated on intrauterine insemination success. Fertil Steril,1997;67:536-541.

6. Auger J, Kunstamann JM, Czyglik F, Jouannet P. Decline in semen quality among fertile men in Paris during the past 20 years. N Engl J Med 1995;332:281-285.

7. Eskenazi B, Wyrobek AJ, Sloter E, Kidd SA, Moore L, Young S, Moore . The association of age and semen quality in healthy men. Hum Reprod 2003;18:447-454.

8. Singh NP, Muller CH, Berger RE. Effects of age on DNA double-strand breaks and apoptosis in human sperm. Fertil Steril 2003;80:1420-1430.

9. Silva LFI, Batista A OJ , Petersen GC, Mauri AL, Massaro FC, Cavagna M, Baruffi RL, Franco JF. The effects of male age on sperm analysis by motile sperm organelle morphology examination (MSOME). Reproductive Biology and Endocrinology 2012; 10:19.

10. The ESHRE Capri Workshop Group, Intrauterine Insemination, Hum Reprod Update 2009;15:265-277.