González-Kladiano D, Armando-Calderón S, Cano-Ramírez C, Soria-Céspedes D

Language: Spanish
References: 13
Page: 116-120
PDF size: 138.63 Kb.

ABSTRACT

Goodpasture’s syndrome also known as anti-GBM antibody disease is an autoimmune disease involving the kidney glomerular basement membrane and lung alveolar basement membrane causing rapid and progressive deterioration in renal function, manifested clinically by oliguria, hematuria and acute renal failure accompanied by cough with bloody sputum and occasionally respiratory failure. The patient with this syndrome experience rapid acute renal failure and early treatment is critical to achieve remission of the disease and prevent kidney dialysis.We report the case of 55 years-old man who was admitted to the emergency department of the ABC Medical Center, with oliguria, hematuria, acute renal failure and cough of 15 days of evolution, secondary to rapidly progressive glomerulonephritis and pulmonary hemorrhage, with the simultaneous presence of high titers of anti-GBM antibodies and antineutrophil cytoplasm antibodies (ANCA). Despite timely initiate specific treatment with hemodialysis, plasmapherisis, cyclophosphamide and methylprednisolone. The patient died three weeks later. Then, the patients with rapidly progressive glomerulonephritis must have an early diagnosis and treatment because it has a high mortality rate. The aim of this paper is to discuss the study and treatment of patients with antibodies to GBM accompanied by pulmonary hemorrhage.

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