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ISSN 1561-2988 (Print)

2013, Number 2

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Rev Cubana Farm 2013; 47 (2)

Simultaneous determination of Albendazol and Triclabendazol in Triclazol 22 suspension for veterinary purposes

García PCM, Gafas LM, Rosales BK, Toirac PR, Pérez CJA

Language: Spanish
References: 11
Page: 167-177
PDF size: 413.56 Kb.


ABSTRACT

Introduction: triclazol 22 suspension containing triclabendazol and albendazol is used as parasiticide for veterinary purposes.
Objective: to validate the analytical method for simultaneous determination of triclabendazol and albendazol in triclazol 22 suspension for quality control.
Methods: for quantitation of the active principle in the final product, the separation was performed through a liquid chromatographic column Lichrosorb RP-18 (5 μm) (250 × 4 mm), with ultraviolet detection range of 298 nm, by using a mobile phase of acetonitrile: ammonium acetate buffer solution of ph 6.6 (70:30); the quantitation was made against a reference sample by means of the external standard method.
Results: the results of the evaluated parameters in this validation yielded that they were within the set limits.
Conclusions: The validated analytical method was linear, precise, exact and specific in the range of studied concentrations.


REFERENCES

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