Gutiérrez-Manjarrez FA, Ruiz-Sandoval JL

Language: Spanish
References: 18
Page: 55-59
PDF size: 91.63 Kb.

ABSTRACT

Dementia is an acquired clinical syndrome, of an organic nature, characterized by impairment of memory and other mental functions, with or without psycho-behavioral symptoms, where he has been excluded from any altered state of consciousness that affects the functioning of the individual’s social activity. Has been described the association of dementia clinically similar to frontotemporal dementia (FTD) and hippocampal sclerosis (HS), where there is severe neuronal loss and gliosis of CA1 of the hippocampus and subiculum. Importantly, the HS has been identified in other cases of primary degenerative diseases, including Alzheimer’s disease (AD), dementia with Lewy bodies, frontotemporal dementia, vascular dementia, and ischemia in patients with bilateral medial temporal lobe, multiple brain infarcts and leukoencephalopathy. We present a 38-year-old woman with severe cognitive impairment and family history of dementia, on the brain image only found the presence of hippocampal sclerosis. We don’t find in the literature descriptions the association of family with dementia and sclerosis hippocampal. We present a brief review of the association of dementia syndrome and hippocampal sclerosis.

REFERENCES

1. Martín M. Consenso Español de Demencias. Sociedad Española de Psicogeriatría. Exter 2005.

2. Burns A, Hope T. Clinical aspect of the dementia of old age. Oxford: Oxford University Press; 1997, p. 456-93.

3. Martín M. La enfermedad de Alzheimer: un trastorno neuropsiquiátrico. Ars Medica 2004.

4. Blass DM, Hatanpaa KJ, Brandt J, Rao V, et al. Dementia in hippocampal sclerosis resembles frontotemporal dementia more than Alzheimer disease. Neurology 2004; 63: 492-7.

5. Ala TA, Beh GO, Frey WH. Pure hippocampal sclerosis. A rare cause of dementia mimicking Alzheimer’s disease. Neurology 2000; 54: 843-8.

6. Kawas CH. Early Alzheimer’s disease. N Engl J Med 2003; 349: 1056-63.

7. Jack CRJr; Dickson DW; Parisi JE; Xu YC, et al. Antemortem MRI findings correlate with hipocampal neuropathology in typical aging and dementia. Neurology 2002; 58: 750-7.

8. Corey-Bloom J, Sabbagh MN, Bondi MW, et al. Hippocampal sclerosis contributes to dementia in the elderly. Neurology 1997; 48: 154-60.

9. Leverenz JB, Agustin CM, Tsuang D, Peskind ER, et al. Clinical and neuropathological chraracteristics of hippocampal sclerosis. Arch Neurol 2002; 59: 1099-06.

10. Dickson DW, Davies P, Bevona C, et al. Hippocampal sclerosis: a common pathological feature of dementia in very old (> 80) humans. Acta Neuropathol 1994; 88: 212-21.

11. Jellinger K. Pure hippocampal sclerosis: A rare cause of dementia mimicking Alzheimer’s disease. Neurology 2000; 55: 735-42.

12. Hatanpaa KJ, Blass DM, Pletnikova O, Crain BJ, et al. Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia. Neurology 2004; 63: 538-42.

13. Chow T, Miller BL, Hayashi VN, Geschwind DH. Inheritance of frontotemporal dementia. Arch Neurol 1999; 56: 817-22.

14. Frisoni GB, Laakso MP, Beltramello A, Geroldi C, et al. Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer’s disease. Neurology 1999; 52: 91-100.

15. Basun H, Almkvist O, Axelman K, Brun A, et al. Clinical characteristics of a chromosome 17-linked rapidly progressive familial frontotemporal dementia. Arch Neurol 1997; 54: 539-44.

16. Lippa CF, Dickson DW. Hippocampal sclerosis dementia. Expanding the phenotypes of frontotemporal dementias?. Neurology 2004; 63: 414-15.

17. Varma AR, Snowden JS, Lloyd JJ, Talbot PR, et al. Evaluation of the NINCDSADRDA criteria in the differentiation of Alzheimer’s disease and frontetemporal dementia. J Neurol Neurosurg Psychiatry 1999; 66: 184-8.

18. Knopman DS, DeKosky ST, Cummings JL, Chui H, et al. Practice parameter: Diagnosis of dementia (an evidence-based review). Neurology 2001; 56: 1143-53.