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Academia Mexicana de Neurología, A.C.

2012, Number 1

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Rev Mex Neuroci 2012; 13 (1)

Von Hippel-Lindau disease simulating acute stroke in the posterior fossa

Chávez CJ, Quintero M, Fuenmayor W, Hernández A, Ojeda IJ

Language: Spanish
References: 19
Page: 60-64
PDF size: 168.40 Kb.


ABSTRACT

Introduction: von Hippel-Lindau disease (VHL) is an autosomal dominant inherited disorder associated with predisposition to central nervous system (CNS) and visceral tumors. Primary or metastatic neoplasias affecting CNS represent frequent conditions that mimic acute stroke. Case report: A 38-year-old normotensive woman presents to our institution with acute-onset headache and posterior fossa focalization. The initial clinical diagnosis was acute stroke, but cerebral magnetic resonances showed a classical image compatible with a non-hemorrhagic cerebellar hemangioblastoma. Multiple cystic adnexal lesions with elevated CA125 cancer antigen were further identified. VHL disease was ultimately diagnosed. Conclusions: All acute-onset focal CNS symptoms accompanied with hypertensive crisis are hemorrhagic strokes until proved otherwise. Nevertheless, CNS tumors without acute hemorrhage can also mimic stroke. As in our case, acute focalization in normotensive individuals should prompt a wider differential diagnosis.


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