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Academia Mexicana de Neurología, A.C.

2013, Number 1

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Rev Mex Neuroci 2013; 14 (1)

Neurological complications of the influenza AH1N1 virus infection in Mexico

González-Duarte A, Soto-Cárdenas K

Language: Spanish
References: 20
Page: 17-20
PDF size: 208.93 Kb.


ABSTRACT

Background: Influenza A(H1N1) infection has been associated with neurological complications, specially in children, although its frequency or the factors that influence its occurrence are unknown. Objectives: To describe the neurologic complications of influenza A(H1N1) infection in a cohort of Mexican adults. Diagnosis was achieved through PCR testing for A(H1N1) in a nasal exudate. Methods: This is a prospective study performed from January 2010 up to April 2012. All neurological signs and symptoms were documented form the beginning of the disease and through all the hospital stay. Results: A total of 118 patients were analyzed with a mean age of 47 ± 18 years. Thirteen cases (11%) had a previous history of neurological disease, but did not show further SNC complications. The most common neurologic manifestation was headache, which occurred in 63(53%) of the cases. Fifteen cases (12%) had diffuse encephalopathy, characterized by headache, sleepiness and dysautonomia. Three cases (2.5%) had neurological sequelae, parkinsonian tremor and muscle rigidity in two and behavioral changes in one. Conclusion: The influenza A(H1N1) infection in adults was associated with diffuse encephalopathy in 12% of the cases. Fortunately, its course was benign, as only 2.5% of the cases presented neurological sequelae.


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