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2013, Number 2

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Rev Cubana Hematol Inmunol Hemoter 2013; 29 (2)

Correlation between ABO blood system and risk of acute myocardial infarction

Toro OC, Vásquez RM, Orrego CR, Maldonado RM, Mujica EV

Language: Spanish
References: 20
Page:
PDF size: 51.69 Kb.


ABSTRACT

Background: among cardiovascular diseases (CVD) acute myocardial infarction (AMI) is included, a disease that currently represents 30 % of total global deaths. The individual predisposition and the presence of traditional risk factors for CVD determine the occurrence of AMI, but there are individuals who suffer an AMI and without these factors. This could be explained by the presence of emerging risk factors, among which is the ABO system blood group.
Aim: to assess the frequency of ABO blood group system in patients with AMI and to investigate the influence it could have on the risk of developing that condition.
Methods: we selected 60 patients with a diagnosis of AMI and 60 with no history of AMI, to which were determined ABO group phenotype and genotype were determined. We used the Chi-square for association between ABO phenotype and the presence of AMI. The associated risk analysis was developed by calculating the odds ratio (OR) with a confidence interval of 95 %.
Results: it was found that in individuals without AMI exists a frequency of 71.7 % of the phenotype «O» exists. In the category marked «No O» phenotypes including A, B and AB, an OR of 2.21 for MI (95% CI 1.04 to 4.72 p = 0.038) was obtained. In relation to genotype, individuals presenting with AMI heterozygous genotypes for allele OR have an OR of 3.17 (95% CI: 1.09 to 9.17 p = 0.034) compared to homozygous. It was established A group of low risk for MI associated with the phenotype-genotype homozygous O and a higher risk group consists of the phenotypes, genotypes A, B and AB was established.


REFERENCES

  1. Departamento de Estadísticas e Información de Salud. Ministerio de Salud de Chile. Disponible enhttp://www.deis.cl/estadisticas-mortalidad/ "Diez principales causas de muerte. Chile 2000 2009. Consultado en Junio 2012.

  2. Hall AS, Barth JH. Universal definition of myocardial infarction. Heart. 2009 Mar;95(3):247-9

  3. Dalmau J. Nuevos factores de riesgo cardiovascular detectable en la edad pediátrica. An Esp Pediatr. 2001; 54(3): 4-8

  4. Wu O; Bayoumi N; Vickers MA; ClarckP. ABO(H) blood groups and vascular disease: a systematic review and meta-analysis. J Thromb Haemost. 2008 Jan; 6(1): 62-9.

  5. van Chie MC; van Loon JE; de Maat MPM; Leebeek FWG. Genetic determinants of von Willerbrand factor levels and activity in relation to the risk of cardiovascular disease: a review. J Thromb Haemost. 2011 May;9(5): 899-908.

  6. Clark P, Wu O. ABO blood groups and thrombosis: a causal association, but is there value in screening? Future Cardiol. 2011 Mar; 7(2):191-201.

  7. Klarmann D, Eggert C, Geisen C, Becker S, Seifried E, Klingebiel T, Kreuz W. Association of ABO(H) and I blood group system development with von Willebrand factor and Factor VIII plasma levels in children and adolescents. Transfusion. 2010; Jul; 50(7):1571-80.

  8. Morelli VM, de Visser MC, van Tilburg NH, Vos HL, Eikenboom JC, Rosendaal FR, et al. ABO blood group genotypes, plasma von Willebrand factor levels and loading of von Willebrand factor with A and B antigens. Thromb Haemost. 2007 Apr; 97(4):534-41.

  9. Palomo I, Icaza G, Mujica V, Nuñez L, Leiva E, Vásquez M. et al. Prevalencia de factores de riesgo cardiovascular clásicos en población adulta de Talca, Chile, 2005. Rev Méd Chile 2007 Jul;135(7): 904-12.

  10. Brecher ME, ed Technical manual. 15th ed. Bethesda MD: American Association of Blood Banks; 2005.p. 289-312.

  11. Lahiri D, Nurnberger J. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res. 1991 Oct;19(19):5444.

  12. Pearson S, Hessner M. A(1,2)BO(1,2) genotyping by multiplexed allele-specific PCR. Br J Haematol. 1998 Jan;100(1): 229-34.

  13. Cadarso-Suarez C. Test Chi-Cuadrado, Asociación de Variables cualitativas o categóricas. Disponible enhttps://www.ucurso. cl/ingenieria/2008/2/INSB58/1/material_docente/bajar?id_material=191462 . Consultado en Junio 2012.

  14. Aedo S, Pavlov S, Clavero F. Riesgo relativo y Odds ratio ¿Qué son y cómo se interpretan? Rev Obstet Ginecol. 2010; 5(1): 51-4.

  15. Milton J. Regresión y Correlación en Estadística para Biología y Ciencias de la Salud 3th ed. Mac Graw-Hill ed. 2001. p. 389-437.

  16. Palomo I, Pereira J Fisiopatología de las citopenias Inmunes. 1th ed. Talca: Universidad de Talca ed.1995. p. 51-8.

  17. Nydegger U, Wuillemin W, Julmy F, Meyer B, Carrel T. Association of ABO histoblood group B allele with myocardial infarction. Eur J Immunogenet. 2003; 30(3): 201- 06.

  18. Schleef M, Strobel E, Dick A, Frank J, Schramm W, Spannagl M. Relationship between ABO and Secretor genotype with plasma levels of factor VIII and von Willebrand factor in thrombosis patients and control individuals. Br J Haematol. 2005 128(1):100-7

  19. Von Beckerath N, Koch W, Mehilli J, Gorchakova O, Braun S, Schomig A, et al. ABO locus O1 allele and risk of myocardial infarction. Blood Coagul Fibrinolysis. 2004;15: 61-7.

  20. O'donnell J, Boulton F, Manning R, Laffan M. Amount of H antigen expressed on circulating von Willebrand factor is modified by ABO blood group genotype and is a major determinant of plasma von Willebrand factor antigen levels. Arterioscler Thromb Vasc Biol. 2002 Feb;22(2):335-41.




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