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ISSN 0864-0289 (Print)

2013, Number 3

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Rev Cubana Hematol Inmunol Hemoter 2013; 29 (3)

Impact of the treatment with adult stem cells in knee osteoarthrosis

Cruz-Sánchez PM, Gámez-Pérez A, Rodríguez-Orta CA, González PY, López GE, Pérez MDS, González GJA, González CF, Pérez LI, Baganet CAM, Escarpanter BJC, Mijares MH, Cruz PY

Language: Spanish
References: 21
Page:
PDF size: 166.64 Kb.


ABSTRACT

Introduction: osteoarthrosis an every day more frequent degenerative disease affecting the quality of life of people over 55 years old and its treatment is a great challenge. The use of stem cells has open a new alternative in the available therapeutic arsenal.
Objective: to assess the efficacy and safety of autologous adult stem cell transplantation in the treatment of knee osteoarthrosis.
Methods: the study took place from May 2009 to December 2011 in 123 adult patients with OAR from the regenerative medicine outpatient service who had no response to conventional treatments. Intra-articular implantation of autologous peripheral blood mononuclear cells (MNC-SP) mobilized by granulocyte colony stimulating factor was performed. In all cases pain and gait difficulty at baseline prevailed.
Results: after six months, clinical and radiological improvement in 117 patients (95,1 %) were observed and only in six patients (4,9 %) the expected response was not obtained. These last patients presented marked alignment disorders and the pain did not disappear, but there was a positive change in its intensity.
Conclusions: the CMN-SP implant is a feasible, simple, safe and less expensive method for the treatment of knee osteoarthrosis. It is recommended that in cases with marked angular deformity, this disorder should be corrected prior to MNC-SP implantation so the procedure be successful.


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