2013, Number 2
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Rev Mex Traspl 2013; 2 (2)
Management of transoperative hyperkalemia in patients with chronic renal failure subjected to renal transplantation
Villegas-Anzo F, Castellanos-Olivares A, Gracida-Juárez C, Rangel-Montes MA, Espinoza-Pérez R, Cancino-López J
Language: Spanish
References: 20
Page: 50-57
PDF size: 232.30 Kb.
ABSTRACT
Introduction: The kidney transplantation is the therapeutic alternative
to improve the quality of the patient’s life with chronic
renal insufficiency; the anesthesiologist should be take account
the characteristic physiopathology for the prevention of the complications
perioperative that include four general conditions:
hyperkalemia, metabolic acidosis, hypertension and azotemia.
The hyperkalemia represents the most important ionic disorder
to correct in the treatments of urgency; the evaluations in the
literature have demonstrated that the infusion of glucose hypertonic
(polarizing solution) with insulin is more effective than
(conventional treatment) with bicarbonate, gluconate of calcium
and hyperventilation.
Objectives: To demonstrate that the decrease
of the values on plasma of potassium is bigger when administers
himself bicarbonate, gluconate of calcium and hyperventilation
in comparison with glucose hypertonic and insulin.
Design: Prospective, comparative and cuasiexperimental study.
Material and methods: 54 patients were studied with levels
subjected high plasma potassium concentrations to surgery of
kidney transplantation from January 1990 to December 1997.
Results: Were formed two groups, one managed with conventional
treatment and other with glucose hypertonic with insulin
treatment 30 patients were formed managed with conventional
treatment being reported levels plasma of K in 6.29 ± 0.43
mEq/L the treatment preoperative was 91.7% of patients with
dialysis and 8.3% with hemodialysis, with age average 33 ± 8.8
years, weight 55 ± 9.9 kg. Group II: solution glucose and insulin the initial levels of K was 7.01 ± 0.66 with descent up to 4.39
± 0.74 mEq/L, the treatment perioperative it was the peritoneal
dialysis in 23 patients (76.7%) and seven with hemodialysis
(23.3%), with average 36 ± 14 years and weight 52 ± 13.7 kg.
Conclusions: The subjected patients to treatment with glucose
an insulin had bigger descent of the levels plasma of K without
tendency to their increase that with the conventional treatment
of bicarbonate, hyperventilation and gluconate of calcium.
REFERENCES
Villegas AF, García HL, Guzmán SJ, Gracida SJ, Melchor OJ, Cedillo LU, Ferrel CP. Anestesia para trasplante renal. Experiencia de 3 años. Rev Mex Anest. 1995; 18: 171-180.
Halabe CJ, Lifshitz GA. Valoración preoperatoria integral en el adulto. 2a ed. Uteha Editorial; 1996: 161-200.
Everts ME, Torben C. Regulation of the Na, K, pump in skeletal muscle. Kidney International. 1989; 35: 1-13.
Kaji DT. Na+ K+ pump in chronic failure. Am J Physiol. 1984; 246: 174-180.
De Fronzo RA. Extrarenal potassium homeostasis. Am J Physiol. 1981; 2: 251-268.
Vaughan RS. The potassium in the preoperative period. BJA. 1991; 67: 192-200.
Sear J. Anesthesia in renal transplantation in Kidney transplantation principles and practice. 4th ed. Philadelphia Pennsylvania: Saunders Company; 1994: 149-163.
Battler D, Salem M. More in therapy for hiperkalemia in renal insuffi ciency. New Eng J Med. 1989; 320: 1496-1497.
Kim JH. Combined effect of bicarbonate and insulin with glucose in acute therapy of hiperkalemia in end stage renal disease patients. Kidney Int. 1992; 41: 369-374.
Blumberg A, Weidmann P, Ferrari P. Effect of prolonged bicarbonate administration on plasma potassium in terminal renal failure. Kidney Int. 1992; 41: 369-374.
Lens M. Treatment of hiperkalemia in renal failure salbutamol versus glucose and insulin. Kidney. 1987; 32: 623-630.
De Fronzo RA, Ferranini E. Effects of graded doses of insulin and potassium peripheral metabolism in man. Am J Physiol. 1984; 246: 174-180.
Fraley D. Correction of hyperkalemia by bicarbonate despite constant blood pH. Kidney Int. 1977; 12: 354-360.
Kemper MJ. Hyperkalemia therapeutic options in acute renal failure. Clin Nephrol. 1996; 46: 67-69.
Jackson MA. Hyperkalemia cardiac arrest successfully treatment with peritoneal dialysis. BMJ. 1996; 312: 1289-1290.
Allon M. Effect of bicarbonate administration on plasma potassium in dialysis patients interactions with insulin and albuterol. Am J Kidney Dis. 1996; 28: 508-514.
Fenton F. Hyperkalemia and digoxin toxicity in a patient with kidney failure. Ann Emerg. 1996; 28: 440-441.
Allon M. Medical and dialytic management of hyperkalemia in hemodialysis in patients with renal failure. In Artif Organs. 1996; 19: 697-699.
Villegas AF, Gracida CJ, Castellanos AO, Rangel MAM. Anestesia para trasplante renal: experiencia de 20 años. Rev Mex Anest. 2010; 35: 167-173.
Gracida CJ, Espinoza RP, Cancino JDL, Ibarra VA, Cedillo UL, Villegas AF, Martínez AJ. Experiencia en trasplante renal en el Hospital de Especialidades “Bernardo Sepúlveda” del Centro Médico Nacional Siglo XXI, IMSS. Rev Inv Clin (RIC). 2011; 63: 19-24.