Akaki CM, Guzmán RAK, Waller GLA, Segura GE

Language: Spanish
References: 8
Page: 146-150
PDF size: 450.21 Kb.

ABSTRACT

Background Recurrent respiratory papillomatosis (RRP) remains a therapeutic challenge, since there is currently no cure for this disease; in addition to the high impact in quality of life of patients. The mechanism of RRP infection is favored by the disruption of the mucous membranes, particularly in the transition zones of two epithelia.
Objective To study the association of the clinical course of recurrent respiratory papillomatosis with gastroesophageal reflux.
Material and method An experimental, observational and prospective study of a consecutive sample of patients with recurrent respiratory papillomatosis was made to research molecular biology, epidemiology, evolution and associated factors.
Results Only one pH-metry showed a pathological report. Six patients had data of gastritis, one of esophagitis and four of incompetent hiatus. Comparing the rate of recurrences per year with reflux, based on the pH-metry, there was no direct association between the rate of recurrences per year and the pathologic result of pH-metry.
Conclusions The results showed that the reflux is not a factor in the course of recurrent respiratory papillomatosis, so there is no data that justify antireflux treatment in patients with this disease.

REFERENCES

1. Dynamed. Updated 2011 Jun. DynaMed Editorial Team. Helicobacter pylori infection. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed/. Updated 2011 Jun.

2. Ford CN. Paradigms and progress in vocal fold restoration. American Laryngological Association. Laryngoscope 2008;118:1709-1713.

3. Goon P, Sonnex C, Jani P, Stanley M, Sudho H. Recurrent respiratory papillomatosis: an overview of current thinking and treatment. Eur Arch Otorhinolaryngol 2008;265:147-151.

4. Bailey BJ. Head & Neck Surgery. Otolaryngology. 4th ed. Philadelphia: Williams & Wilkins, 2006.

5. Shizue S, Pignatari N, Guzmán-Liriano RY, et al. Gastroesophageal reflux in patients with recurrent laryngeal papillomatosis. Rev Bras Otorrinolaringol 2007;73:210-214.

6. Stern Y, Felipovich A, Cotton RT, Segal K. Immunocompetency in children with recurrent respiratory papillomatosis: Prospective study. Ann Otol Rhinol Laryngol 2007;116:169-171.

7. Salis G. Revisión sistemática: epidemiología de la enfermedad por reflujo gastroesofágico en Latinoamérica. Acta Gastroenterol Latinoam 2011;41:60-69.

8. Holland BW, Koufman JA, Postma GN, McGuirt WF. Laryngopharyngeal reflux and laryngeal web formation in patients with pediatric recurrent respiratory papillomas. Laryngoscope 2002;112:1926-1929.