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Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado

2013, Number 3

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Rev Esp Med Quir 2013; 18 (3)

Polyostotic Fibrous Dysplasia with Injury to Thoracic Spain

Flores RMÁ, Rodríguez MAF, Fernández LCG, Díaz VJJ, Hernández GLS

Language: Spanish
References: 16
Page: 271-276
PDF size: 209.67 Kb.


ABSTRACT

Fibrous dysplasia is a single or multiple benign osteofibrous lesion with a low and gradual replacement of lamellar bone with fibrous tissue containing isomorphic trabeculae of abnormal and small immature bone tissue, consisting of a metaplasia of the bone fibrous stromal, caused by a mutation in the G protein subunit Gs on chromosome 20 and described by Lichtenstein and Jaffe in 1942. The most common sites of the disease are all long bones, craniofacial bones, ribs and pelvis; rare column about 4.2% and the most affected area is back. The objective of this article is to report the case of a patient with thoracic spine involvement because it is a rare site of presentation, without typical symptoms, being a radiographic finding. Likewise, treatment with the use of a monoclonal antibody to RANKL, although it is not a specific therapy for this disease, has shown good results.


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