Jaime-Pérez JC, Reyes-Escobedo A, González-Llano Ó, Herrera-Garza JL, Marfil-Rivera LJ, Gómez-Almaguer D

Language: Spanish
References: 20
Page: 124-130
PDF size: 403.87 Kb.

ABSTRACT

Background: The survival of pediatric patients with acute lymphoblastic leukemia (ALL) has been rising substantially. The relationship between response to treatment and nutritional status at diagnosis is not clear, especially in patients who have overweight or obesity.
Objective: We evaluated if nutritional status at diagnosis is related to the survival and risk of relapse.
Material and methods: We studied data from 153 patients younger than 16 years from November 2001 to August 2012. Body mass index (BMI) was used and patients were classified as underweight, normal weight, overweight and obese according to percentile for age, based on reference tables from the World Health organization (WHO).
Results: 79 (51.6%) patients were males and 74 (48.4%) females. The median age at diagnosis was 5 (2-16) years, median of follow-up was 57 (1.51-148.9) months. Variables for unfavorable prognosis at multivariate analysis were high risk at diagnosis (p=0.030 [CR 2.29]), underweight (p=0.05 [CR 2.37]). In univariate analysis high risk and relapse remained as poor prognosis factors (p=0.011 vs p=0.0001 respectively). Kaplan-Meier analysis showed significant differences in overall survival (OS) between relapse vs no relapse (50.6% vs 86.3%, p = 0.0001), and high risk vs standard risk (SG 60.5% vs 78.8%, p = 0.009).
Conclusion: Nutritional status as a single factor at ALL diagnosis was not a risk factor. A tendency to a higher OS in the overweight and obese children group was found.

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