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ISSN 2007-6800 (Print)

2013, Number 3

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Rev Mex Traspl 2013; 2 (3)

Neuropsychological effects during early childhood in children exposed to immunosuppressants in intrauterine development. Immunosuppressants and long-term cognitive effects

Lascarez S, Vélez A, Sánchez S, Orozco G, Cruz F

Language: Spanish
References: 44
Page: 107-114
PDF size: 221.96 Kb.


ABSTRACT

Mexico ranks ninth in kidney transplants, a procedure practiced in the ages of highest productivity, affecting various aspects such as procreation. Concerning pregnancy care, opinions are diversified as to how long to wait after a kidney transplant, as well as the consequences of the use of immunosuppressants. However, constant characteristics include low birth weight and preterm births, which derive significant cognitive impairment; its severity determining their impact. These implications are secondary to the use of immunosuppressants; we could therefore hypothesize that they can cause alterations in executive function, attention, memory, language and motor development; nevertheless the question arises of whether these alterations are also present in infants that were exposed to immunosuppressants but did not have low birth weight or preterm birth. Still no studies are available that directly correlate immunosuppressants with cognitive alterations, so a wide field of research remains open.


REFERENCES

  1. Centro Nacional de Trasplantes. Estado actual de donación y trasplantes en México. Reporte anual 2011. México: CENATRA; 2011.

  2. Romero JF, Ayala JA, Jiménez G. Embarazo en pacientes con trasplante renal: morbilidad materna y fetal. Ginecol Obstet Mex. 2008; 76: 643-651.

  3. Tendron A, Gouyon JB, Decramer S. In utero exposure to immunosuppressive drugs: experimental and clinical studies. Pediatr Nephrol. 2002; 17: 121-130.

  4. Iglesias MC, Delgado M. Embarazo gemelar en pacientes con trasplante renal y ciclosporina A. Enferm Nefrol. 1988; 297-298.

  5. Cimaz R, Meregalli E, Biggioggero et al. Alterations in the immune system of children from mothers treated with immunosuppressive agents during pregnancy. Toxicology Letters. 2004; 149: 155-162.

  6. Biggioggero M, Borghi M, Gerosa M, Trespidi L, Cimaz R, Meroni P. Immune function in children born to mothers with autoimmune diseases and exposed in utero to immunosuppressants. Lupus. 2007; 16: 651-656.

  7. Deshpande NA, James NT, Kucirka LM et al. Pregnancy outcomes in kidney transplant recipients: a systematic review and metaanalysis. Am J Transplant. 2011; 11: 2388-2404.

  8. Centro Nacional de Trasplantes. Informe anual 2011 sobre donación y trasplantes [Internet]. 2012. [consultado el 13 de Marzo del 2012; citado el 5 de Enero del 2012]. Disponible en: http://www.cenatra.salud.gob.mx/descargas/contenido/trasplante/reporte_anual_2011.pdf

  9. Hou S. Pregnancy in chronic renal insufficiency and end-stage renal disease. Am J Kidney Dis. 1999; 33: 235-252.

  10. Radomski JS, Ahlswede BA, Jarrell BE et al. Outcomes of 500 pregnancies in 335 female kidney, liver, and heart transplant recipients. Transplant Proc. 1995; 27: 1089-1090.

  11. Armenti VT, Ahlswede KM, Ahlswede BA, Jarrell BE, Moritz MJ, Burke JF. National transplantation pregnancy registry –outcomes of 154 pregnancies in cyclosporine-treated female kidney transplant recipients. Transplantation. 1994; 57: 502.

  12. Armenti VT, Moritz MJ, Davison JM. Pregnancy in female pediatric solid organ transplant recipients. Pediatr Clin North Am. 2003; 50: 1543-1560.

  13. Armenti VT, Moritz MJ, Cardonick EH, Davison JM. Immunosuppression in pregnancy: choices for infant and maternal health. Drugs. 2002; 62: 2361-2375.

  14. Pallardo M, Crespo F. Embarazo y trasplante renal: luces y sombras. Nefrología. 2008; 28 (2): 148-150.

  15. Azocar M. Síndrome nefrótico y el diagnóstico genético en pediatría. Revista Chilena de Pediatria. 2011; 82 (1): 12-20.

  16. McKay DB, Josephson MA. Pregnancy in recipients of solid organs –effects on mother and child. N Engl J Med. 2006; 354: 1281-1293.

  17. Tendron FA, Gouyon JB, Guignard JP, Decramer S, Justrabo E, Gilbert T et al. Long-term effects of in utero exposure to cyclosporin A on renal function in the rabbit. J Am Soc Nephrol. 2004; 15: 2687-2693.

  18. Fumero RA, Cobas LR, Santiago MA. Repercusion de los factores de riesgo en el bajo peso al nacer. Resumed; Ministerio de Salud publica. 2001; 14 (3): 117-124.

  19. Kociszewska NB, Pietrzak B, Cyganek A, Szpotanska SM, Schreiber ZJ, Jabiry ZZ et al. Intrauterine hypotrophy and premature births in neonates delivered by female renal and liver transplant recipients. Transplantation Proceedings. 2011; 43: 3048-3051.

  20. López V, Martínez D, Viñolo C, Cabello M, Solá E, Gutiérrez C et al. Pregnancy in kidney transplant recipients: effects on mother and newborn. Transplant Proc. 2011; 43: 2177-2178. doi: 10.1016/j.transproceed.2011.05.026.

  21. Al-Khader AA, Basri N, Al-Ghamdi, Shaheen, Hejaili, Flaiw et al. Pregnancies in renal transplant recipients –with a focus on babies. Ann Transplant. 2004; 9 (3): 65-67.

  22. Einollahi B, Rostrami Z, Kalantar E, Lessan M, Pourfarziani V, Nemati E. Is the lower cyclosporine concentration at 2 hours after dosing safe in kidney tranplant recipients? Transplantation Proceedings. 2011; 43: 488-490.

  23. Nulman I, Sgro M, Barrera M. Long-term neurodevelopment of children exposed in utero to ciclosporin after maternal renal transplant. Pediatric drugs. 2010; 12 (2): 113-122.

  24. Hack M, Flannery DJ, Schlucther M, Cartan L, Borawski E. Outcomes in young adultood for vey low birth weight infants. The New England Journal of Medicine. 2002; 346 (3): 149-157.

  25. Peterson B, Anderson A, Ehrenkranz W, Staib R, Tageldin L, Colson M et al. Regional brain volumes and their later neurodevelopmental correlate in term and preterm infants. Pediatrics. 2003; 11 (5): 939-948.

  26. Peterson B. Brain imaging studies of the anatomical and functional consequences of preterm birth for human brain development. Annals of the New York Academy of Sciences. 2003; 1008: 219-237.

  27. Taylor HG, Burant CJ, Holding PA, Klein N, Hack M. Sources of variability in sequelae of very low birth weight. Child Neuropsychology. 2002; 8 (3), 163-178.

  28. Fumero RA, Cobas LR, Santiago MA. Repercusion de los factores de riesgo en el bajo peso al nacer. RESUMED. 2001; 14 (3): 115-21.

  29. Aarnoudse-Moens CS, Weisglas-Kuperus N, Goudoever JB, Oosternalaan J. Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children. Pediatrics. 2009; 124: 717-728.

  30. Geldof C, Wassenaer AG, Kieviet J, Kod JH, Oosterlaan.J. Visual perception and visual-motor integration in very preterm and/or very low birth weight children: a meta-analysis. Research in developmental disabilities. 2012; 2 (33): 726-736.

  31. Strang-Karlsson, Andersson S, Paile-Hyvarienen S. Slower reaction times and impaired learning in youth adults with birth weight. Pediatrics. 2010; 125: 74-82.

  32. Barde LH, Yeatman JD, Lee ES, Glover G, Felman HM. Differences in neural activation between preterm and full term born adolescents on a sentence comprehension task; implications for educational accommodations. Developmental Cognitive Neuroscience. 2012; 2: S114-S128.

  33. Flacking R, Ewald U, Nyqvist KH, Starri B. Trustful bonds: a key to “becoming mother” and to reciprocal breastfeeding. Stories of mothers of very preterm infants at neonatal unit. Social Science and Medicine. 2006; 62: 70-80.

  34. Nogueira J, Laynez C, Cruz-Quintana F, Perez-García M. Neuropsychological evaluation of high-risk children from birth to seven years of age. The Spanish Journal of Psychology. 2012; 15 (1): 101-111.

  35. Hack M, Flannery DJ, Schlucther M, Cartan L, Borawski E. Outcomes in young adultood for vey low birth weight infants. The New England Journal of Medicine. 2002; 346 (3): 149-157.

  36. Meere J, Börger NA, Potgieter ST, Pirina S, Cock PD. Very low birth weight and attention deficit/hyperactivity disorder. Child Neuropsychology. 2009; 15: 605-618.

  37. Indredavik M, Vik T, Heyerdahl S, Kulseng S. Psychiatric symptoms and disorders in adolescents with low birth weight. Archives of Pediatic and Adolescent Medicine. 2004; 164: 525-532.

  38. Lundequist A, Böhm B, Smedler AC. Individual neuropsychological profiles at age 5 1/2 years in children born preterm in relation to medical risk factors. Child Neuropsychology. 2013; 19 (3): 313-331.

  39. Rose SA, Feldman JF, Jankowski J. Information processing in toddlers: continuity from infancy and persistence of preterm deficits. Intelligence. 2009; 37: 311-320.

  40. Lind A, Korkman M, Lehtonen L, Parkkola H, Matomaki J. Cognitive and neuropsychological outcomes at 5 years of age in preterm children born in the 200s. Developmental Medicine and Child Neurology. 2011; 53 (3): 256-262.

  41. Leversen KT, Sommerfelt K, Kaaresen A, Farstad P, Skranes TE. Prediction of neurodevelopmental and sensory outcome at 5 years in Norwegian children born extremely preterm. Pediatrics. 2011; 127: 630-638.

  42. Ment L, Vohr B, Allan W, Kratz K, Schenider K, Westerveld M et al. Change in cognitive function over time in very low birth weight infants. The Journal of the American Medical Association. 2003; 28 (9): 705-712.

  43. Schafer RJ, Lacadie C, Vohr B, Katz SR, Schneider KH. Alterations in functional connectivity for language in prematurely born adolescents. Brain. 2009; 132: 661-670.

  44. McCoy TE, Conrad AL, Richman LC, Nopoulos PC, Bell EF. Memory processes in learning disability subtypes of children born preterm. Child Neuropsychology. 2013; 19 (2); 173-189.




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