López-Velázquez JA

Language: Spanish
References: 41
Page: 228-234
PDF size: 430.58 Kb.

ABSTRACT

Bilirubin is the main pigment in bile. Is formed in endoplasmic reticulum from heme group breakdown. In 1916 it was first identified in pigmented bodies, and until 1950, was considered only a waste product. However, currently bilirubin is one of the liver function test, included to determine hepatocyte excretion. Therefore, molecular, biochemical, and clinical studies have allowed it several beneficial functions as a potent antioxidant to slightly elevated plasma concentrations but also has been attributed a toxic role in nerve cells at high concentrations. Because of its complex structure and being a photosensitive molecule, it has been difficult to study their chemical properties. Researches to clarify their physicochemical properties took boom following the description of the role of hyperbilirubinemia in the newborn (kernicterus). The current outlook is focus on the study of antioxidant property and their possible therapeutic implications in diabetes, cardiovascular disease and other related diseases. This review demonstrates the clinical significance of bilirubin from the understanding of the structure and biochemistry in the body, as well as the physiological implications that have become it more than just a yellow waste.

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