>Gaceta Médica de México
>Year 2003, Issue 4
Millán-Guerrero RO, Vázquez C, Isais-Aguilar L, Trujillo-Hernández B
Hyperhomocysteinemia in Acute Cerebral Infarct.
Gac Med Mex 2003; 139 (4)
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Antecedents: Hyperhomocysteinemia has recently been recognized as contributing
directly or associatively to the arteriosclerotic process in cerebral infarction.
Objective: To determine plasmatic homocysteine levels in with patients with
acute cerebral infarction and to seek an association between clinical sub-types
of cerebral lesion and homocysteine levels and risk factors present.
Material and Methods: A descriptive study was carried out on patients diagnosed
with acute cerebral infarction. The study included 22 patients of both sexes
between the ages of 40 and 85 years. Samples were collected on the second day
of hospitalization after 12 h of fasting.
Results: In 13 of 22 patients, elevated levels of serum homocysteine were found.
The homocysteine average was 20-68 mmol/ L ±
9.6 SD. No association between degree of cerebral lesion and risk factors was
found (p > 0.05).
Conclusion: An increase in homocysteine was found in 59% of cerebral infarction
patients. No correlation between hyperhomocysteinemia and known risk factors
such as smoking, alcoholism, high blood pressure, and diabetes was found. It
is necessary to continue this line of investigation to identify conditioning
factors that elevate homocysteine and to implement measures to lower levels
of hyperhomocysteinemia, thus helping reduce the incidence of cerebrovascular
||Homocysteine serum, cerebral infarction.
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>Gaceta Médica de México
>Year 2003, Issue 4