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>Journals >Revista Médica MD >Year 2013, Issue 2

Contreras-Omaña R, García-Samper MAX, Bernardo-Escudero R, Montaño-Estrada LF
Serum levels of Interleukin 15, nitric oxide and insulin in patients with chronic Hepatitis C infection
Rev Med MD 2013; 4.5 (2)

Language: Español
References: 18
Page: 60-65
PDF: 622.83 Kb.

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The present study analyzed blood samples from 55 chronic HCV infected patients from both sexes, with the aim of measuring serum levels of IL-15, Nitric Oxide and insulin, three molecules which are known to influence in a very important way t regulatory, immune and inflammatory pathways in the liver.
Once measurements were obtained, we proceeded to compare them with each other, searching to detect the presence or absence of a relationship between values. Our goal was to establish new possible physiopathological interactions that may lead to a better understanding of the disease.
As a result we obtained the following data: in most of the studied patients, the IL-15 levels were importantly diminished or absent, showing a significant relationship with the Nitric Oxide levels (p=0.003) in the bi-variable analysis. On the contrary, serum insulin levels were always found between normal values in almost all samples, and they didn´t show a significant relationship with any of the other two molecules either.
Considering all the previous data, we reached the conclusion that in the majority of patients chronically infected with HCV in this study, the almost undetectable levels of IL-15 may in part explain the viral evolution to chronicity, and on the other hand, regardless of the normal serum insulin levels there was no correlation with IL-15 values. Nitric Oxide levels did show a significant relationship with the presence or absence of this cytokine. This may suggest the presence of a significant physiopathological nexus between production and manifestation of both molecules, although more studies to precisely establish this association are still needed.

Key words: Hepatitis C, interleukin 15, nitric oxide, insulin, chronic liver damage.


  1. Guillou-Guillemet H Le et al; “Genetic diversity of the Hepatitis C Virus: Impact and issues in the antiviral therapy”; World J Gastroenterol. 2007;13(17):2416-2426

  2. 2.Joerg Timm, Michael Roggendorf; “Sequence diversity of Hepatitis C Virus: Implications for immune control and therapy”; World J Gastroenterol. 2007;13(36):4808-4817

  3. Henry Radziewicz et al; “Memory CD8+-T cell differentiation in viral infection: a cell for all seasons”. World J Gastroenterol 2007:13(36):4848-4857

  4. Medicina Molecular de FIBAO: “Inteferón gamma”. 2007- 10-16. www.medmol.es

  5. Ute-Christiane Meier et al; “Shared Alterations in NK Cell Frequency, Phenotype, and Function in Chronic Human Immunodeficiency Virus and Hepatitis C Virus Infections”. Journal of Virology. 2005;12365- 12374

  6. Ursula Plöckinger MD, et al; “Hepatitis-C Patients Have Reduced Growth Hormone (GH) Secretion Wich Improves During Long-Term Therapy With Peg ylatedInteferon-alfa. Am J Gastroenterol. 2007;102:2724-2731

  7. Richard Fischer et al; “ Hepatitis C virus infection and apoptosis”. World J Gastroenterol 2007;13(36):4865- 4872

  8. Elaine F. Meurs, AdrienBreiman; “The Interferon Inducing Pathways and the Hepatitis C Virus”; World J Gastroenterol. 2007; 13(17): 2446-2454

  9. Friedemann Weber; “Interaction of hepatitis C virus with the type I interferon system”. World J Gastroenterol 2007 September 28; 13(36): 4818-4823

  10. 10.Izzo F. et al; “Pegylated arginine deaminase lowers hepatitis C viral titers and inhibits nitric oxide synthesis”. J Gastroenterol Hepatol. 2007 Jan; 22(1) 86- 91

  11. Strickler HD et al; “The Insulin-like growth factor axis and the risk of liver disease in Hepatitis C Virus/HIV co-infected women”. AIDS 2008;22(4):527-531

  12. Francesco Negro, MahnazAlaei; “Hepatitis C Virus and type 2 diabetes”. World J Gastroenterol.2009; 15(13): 1537-1547

  13. Burton JD, Bambford RN et al; “A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukaemia line, stimulates Tcell proliferation and the induction of lymphokineactivated killer cells”. PNAS. 1994;91:4935-4939

  14. Grabstein KH et al; “Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor”. Science. 1994;264:965-968

  15. Alicia Santos Savio; “Interleucina-15: una citocina relevante en la homeostasis linfoide y en enfermedades autoinmunes”. Biotecnología Aplicada. 2006;23:79-86

  16. Vincenzo Barnaba; “Hepatitis C virus infection: A 'liaison a trois' amongst the virus, the host, and the chronic low-level inflammation for human survival”. Journal of Hepatology 210, vol. 53; 752-761

  17. Ueda T et al; “Serum interleukin-15 level is a useful predictor of the complications and mortality in severe acute pancreatitis”. Surgery 2007;142(3):319-326

  18. Pappa C et al; “Serum levels of interleukin-15 and interleukin-10 and their correlation with proliferating cell nuclear antigen in multiple myeloma”. Cytokine 2007;37(2):171-175

>Journals >Revista Médica MD >Year 2013, Issue 2

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