medigraphic.com
Colegio de Medicos y Cirujanos República de Costa Rica

2013, Number 608

<< Back Next >>

Rev Med Cos Cen 2013; 70 (608)

Carbapenémicos: Tipos y mecanismos de resistencia bacterianos

Moreno MKM

Language: Spanish
References: 10
Page: 599-605
PDF size: 214.08 Kb.


ABSTRACT

Carbapenems are β-lactam antibiotics endowed with a broader spectrum, activity and resistance to β-lactamases than other β-lactams. All available carbapenems have similar spectrum, although there are significant differences in their antimicrobial activity, which in the long run determines the clinical indications of each carbapenem. Bacteriae use different mechanisms to defend themselves from antibiotics which are constantly evolving. Carbapenemases or AmpC enzyme hyperproduction in combination with other mechanisms produce the rapid emergence of resistant strains. This review describes the most frequently used mechanisms of resistance by these germs against carbapenems.


REFERENCES

  1. Bennett, JW., Herrera ML., Lewis II, JS., Wickes, BW., Jorgensen JH. (2009) KPC-2-Producing Enterobacter cloacae and Pseudomonas putida Coinfection in a Liver Transplant Recipient. Antimicrob. Agents Chemother. 53 (1) 292-294.

  2. Bush, K., Fisher, JF. (2011) Epidemiological Expansion Structural Studies, and Clinical Challenges of New β-Lactamases from Gram-Negative Bacteria. Annu. Rev. Microbiol. 65: 455-478.

  3. Bush, K., Jacoby, G. (2010) Updated Functional Classification of β-Lactamases. Antimicrob. Agents Chemother. 54 (3): 969-976.

  4. Fresnadillo Martínez, MJ., García García, MI., García Sánchez, E., García Sánchez, JE. (2010) Los carbapenems disponibles: propiedades y diferencias. Enferm. Infecc. Microbiol. Clin. 28 (2):53- 64.

  5. Galdiero, S., Falanga, A., Cantisani, M., Tarallo, R., Della Pepa, ME., D’Oriano, V., Galdiero, M. (2012) Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins. Curr. Prot.Pept. Sci. 13: 843- 854.

  6. Jacoby, GA., Mills DM., Chow N. (2004) Role of β-Lactamases and Porins in Resistance to Ertapenem and other β-Lactams in Klebsiella pneumoniae. Antimicrob. Agents Chemother. 48 (8) 3203-3206.

  7. Kitchel, B., Rasheed, K., Endimiani, A., Hujer, A., Anderson,K., Bonomo, R., Patel, J. (2010). Genetic Factors Associated with Elevated Carbapenem Resistance in KPCProducing Klebsiella pneumoniae. Antimicrob. Agents Chemother. 54 (10): 4201-4207.

  8. Le, J., Castanheira, M., Burgess, D., McKee, B., Iqbal, R.,Jones, R. (2010) Clonal Dissemination of Klebsiella pneumoniae Carbapenemase KPC- 3 in Long Beach, California J. Clin. Microbiol., 48 (2): 623–625.

  9. Leavitt, A., Chmelnitsky, I., Colodner, R., Ofek, I., Carmeli, Y., Navon-Venezia, S. (2009) Ertapenem Resistance among Extended-Spectrum- β-Lactamase- Producing Klebsiella pneumoniae Isolates_ J. Clin. Microbiol. 47 (4): 969–974.

  10. Martínez- Martínez L., Calvo J. (2010) El problema creciente de la resistencia antibiótica en bacilos gramnegativos: situación actual. Enferm Infecc Microbiol Clin. 28: 25-31.




2020     |     www.medigraphic.com