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>Journals >Cirujano General >Year 2005, Issue 4

Vásquez CS, Alcántara MF, Gracida MN, Corona CF, Palomeque LA, Ramírez VJ, Basurto KE
Efficacy of a single cephalothin (2 g iv) dose as prophylactic antibiotic for inguinal mesh repair
Cir Gen 2005; 27 (4)

Language: Español
References: 25
Page: 269-274
PDF: 4. Kb.

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Objective:To assess the usefulness of administering a single cephalothin dose (2 g, IV) as prophylactic antibiotic in preventing infection at the operation site when performing an open inguinal repair with prosthetic material (polypropylene mesh).
Setting:Third level health care hospital.
Design:Experimental, prospective, longitudinal, comparative, randomized and double-blind study.
Statistical analysis:Percentages (qualitative variables) compared by means of Chi square, α = 0.05.
Results:Sampling was cut at 160 patients (with antibiotic n = 68 and without n = 92), infection at the superficial surgical site presented globally in two (1.25%) patients; both from the non-antibiotic group (2.17%) without statistical significance (p = 1.49). Neither group presented deep infection at the surgical site.
Conclusion:Cephalothin administration (2 g, IV) as prophylactic antibiotic to prevent infection of the surgical wound, when performing open inguinal repair with prosthetic material (mesh), has not shown any benefits yet.

Key words: Prophylactic antibiotic, inguinal hernia, infection of the surgical site.


  1. Emori TG, Culver DH, Horan TC, Jarvis WR, White JW, Olson DR, et al. National Nosocomial Infections Surveillance System (NNIS): description of surveillance methods. Am J Infect Control 1991; 19: 19-35.

  2. National Center for Health Statistics. National Hospital Discharge Survey: Detailed Diagnoses and Procedures 1994. Series 13, No. 127. http://www.cdc.gov/nchs/data/series/sr_13/sr13_127.pdf

  3. Cruse PJ. Wound Infection Surveillance. Rev Infect Dis 1981; 3: 734-7.

  4. Cruse PJ, Foord R. The epidemiology of wound infection: a 10 year prospective study of 62,939 wounds. Surg Clin North Am 1980; 6: 27-40.

  5. Martone WJ, Jarvis WR Culver DH, Haley RW. Incidence and nature of endemic and epidemic nosocomial infections In: Bennett JV, Braccmann PS, eds. Hospital infections. 3rd ed. Boston, little brown ad Co. 1992: 577-96.

  6. Boyce JM, Potter-Bynoe G, Dziobeck L. Hospital Reimbursement patterns among patients with surgical wound infections following open heart surgery. Infect Control Hosp Epidemiol 1990; 11: 89-93.

  7. Poulsen KB, Bremmelgaard A, Sorensen AI, Raaheve D, Petersen JV. Estimated costs of postoperative wound infections. A case-control study of marginal hospital and social security costs. Epidemiol Infect 1994; 113: 283-95.

  8. Vegas AA, Jodra VM, Garcia ML. Nosocomial infection in surgery wards: A controlled study of increased duration of hospital stays and direct cost of hospitalization. Eur J Epidemiol 1993; 9: 504-10.

  9. Albers BA, Patka P, Haarman HJ, Kostense PJ. Cost effectiveness of preventive antibiotic administration for lowering risk of infection by 0.25%. Unfallchirurg 1994; 97: 625-8.

  10. Platell C, Hall J. What is the role of mechanical bowel preparation in patients undergoing colorectal surgery? Dis Colon Rectum 1998; 41: 875-82: discussion 882-3.

  11. Clarke JS, Condon RE, Bartlett JG, Gorbach SL, Nichols RL, Ochi S. Preoperative oral antibiotics reduce septic complications of colon operations: results of prospective, randomized, double-blind clinical study. Ann Surg 1977; 186: 251-9.

  12. Hill C, Flamant R, Mazas F, Evrard J. Prophylactic cefazolin versus placebo in total hip replacement. Report of a multicentre double-blind randomized trial. Lancet 1981; 1(8224): 795-6.

  13. Kaiser AB, Petracek MR, Lea JW 4th, Kernodle DS, Roach AC, Alford WC Jr, et al. Efficacy of cefazolin, cefamandole, and gentamicin as prophylactic agents in cardiac surgery. Results of a prospective, randomized, double-blind trial in 1,030 patients. Ann Surg 1987; 206: 791-7.

  14. Sanchez–Manuel FJ, Seco-Gil, JL. Antibiotic prophylaxis for hernia repair. Cochrane Database Syst Rev 2004; (4): CD003769.

  15. Schumpelick V, Treuner KH, Arlt G. Inguinal hernia repair in adults. Lancet 1994; 344(8919): 375-9.

  16. Medina M, Sillero M, Gallego GM, et al. Risk factors of surgical wound infection in patients undergoing herniorrhaphy. Eur J Surg 1997; 163: 191-8.

  17. Gilbert AI, Felton LL. Infection in inguinal hernia repair considering Biomaterials and antibiotics. Surg Gynecol Obstet 1993; 177: 126-30.

  18. Yerdel MA, Akin EB, Dolalan S, Turkcapar AG, Pehlivan M, Gecim IE, et al. Effect of single-dose prophylactic ampicillin and sulbactam on wound infection after tension-free inguinal hernia repair with polypropylene mesh: the randomized, double-blind, prospective trial. Ann Surg 2001; 233: 26-33.

  19. Platt R, Zaleznik DF, Hopkins CC, Dellinger EP, Karchmer AW, Bryan CS, et al. Perioperative antibiotic prophylaxis for herniorrhaphy and breast surgery. N Engl J Med 1990; 322: 153-60.

  20. Glassow F. Is postoperative wound infection following simple inguinal herniorrhaphy a predisposing cause of recurrent hernia? Can Med Assoc J 1964; 91: 870-1.

  21. Mann DV, Prout J, Havranek E, Gould S, Darzi A. Late-onset deep prosthetic infection following mesh repair of inguinal hernia. Am J Surg 1998; 176(1): 12-4.

  22. Zollinger RM Jr. Classification systems for groin hernias. Surg Clin North Am 2003; 83: 1053-63.

  23. Mangram AJ, Horan TC, Pearson ML, Silver LC, Jarvis WR Guideline for prevention of surgical site infection, 1999. Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol 1999; 20: 250-78; quiz 279-80.

  24. World Medical Association declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects. JAMA 1997; 277: 925-6.

  25. The Nuremberg Code. JAMA 1996; 276: 1691.

>Journals >Cirujano General >Year 2005, Issue 4

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