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Anales de Otorrinolaringología Mexicana

Anales de Otorrinolaringología Mexicana
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2014, Number 1

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Otorrinolaringología 2014; 59 (1)

Identification of Citrobacter koseri as a New Pathogen in Patients with Chronic Rhinitis

Daza HAL, Arroyo ES, Bravo EGA
Full text How to cite this article

Language: Spanish
References: 9
Page: 1-10
PDF size: 1477.00 Kb.


Key words:

Citrobacter, chronic rhinitis, nasal infection.

ABSTRACT

Background: Chronic rhinitis, characterized by irritation and persistent inflammation of the nasal mucosa, is caused generally by Staphylococcus aureus and Klebsiella. Citrobacter koseri is an opportunistic bacterium, not recognized as a pathogen of the respiratory tract and not reported previously as cause of disease in otolaringology, mainly it has been reported as cause of meningitis in neonates and immunocompromised patients as a severe acute infection; it has been described that in other anatomical sites destroys the microvilli.
Objective: To know the cause of chronic rhinitis and to identify possible new cases.
Material and method: A descriptive, retrospective, longitudinal, analytic study was performed with 25 records of patients attended at the Service from September 2011 to March 2012 with chronic nasal inflammatory manifestations without response to conventional therapy, in whom cultures of nasal secretion by means of endoscopy, computed tomography of nose and paranasal sinuses, laboratory samples including cANCAS, and biopsy with histopathologic study and stains (Warthin-Starry and Zielh-Neelsen) were done, looking for identifying the etiology of inflammatory processes and to discard diseases that could jeopardize the immunity of the individuals.
Results: In addition to the known germs producing chronic rhinitis, in the cultures of the 25 studied cases, 4 cases of Citrobacter koseri were identified, in isolated form in one and as a copathogen in 3, presenting as indolent nasal chronic infection in immunocompetent patients.
Conclusions: Citrobacter koseri must be included among the differential diagnosis of chronic rhinitis, being differentiated from other diseases such as rhinoscleroma, tuberculosis and Wegener granulomatosis.


REFERENCES

  1. Gutiérrez MS, Barreto PT. Rinitis atrófica como causa del síndrome de nariz vacía. Acta de Otorrinolaringología & Cirugía de Cabeza y Cuello 2010;38:437-441.

  2. Koneman E, Allen S, et al. Diagnóstico Microbiológico. 5ª ed. Panamerica, 1999;192:206-207.

  3. Terence ID. The role of Citrobacter in clinical disease of children: Review. Clin Infect Dis 1999;28:384-394

  4. Mcpherson C, Gal P, Ransom JL. Treatment of Citrobacter koseri infection with ciprofloxacin and cefotaxime in a preterm infant. The annals of pharmacotherapy. Ann Pharmacother 2008;42:1134-1138.

  5. Mavroidi A, Neonakis I, Liakopoulos A, Papaioannou A. Detection of Citrobacter koseri carrying beta-lactamase KPC-2 in a hospitalised patient. Euro Surveill 2011;16:41-43.

  6. Shuliang Liu. Myd88 is pivotal for immune recognition of Citrobacter koseri and astrocyte activation during CNS infection. J Neuroinflamm 2011;8:35-49.

  7. Stacy MT. Flip influences Citrobacter koseri macrophage uptake, cytokine expression and brain abscess formation in the neonatal rat. J Medical Microbiology 2006;55:1631- 1640.

  8. Underwood S, Avison M. Citrobacter koseri and Citrobacter amalonaticus isolates carry highly divergent β-lactamase genes despite having high levels of biochemical similarity and 16S rRNA sequence homology. J Antimicrob Chemother 2004;53:1076-1080.

  9. Wilhelm F. Correct names of the species Citrobacter koseri, Levinea malonatica, and Citrobacter diversus. Request for an opinion. Int J Syst Bacteriol 1990;40:107-108.




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Otorrinolaringología. 2014;59