2014, Number 2
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ABSTRACTBackground: Adipocytokines are adipocyte-secreted peptides that are involved in the pathways that lead to insulin resistance, inflammation and the development of cardiovascular disease.
Objective: To evaluate the levels of the adipocytokines resistin and adiponectin in normotensive and hypertensive diabetic patients.
Material and methods: Clinical and transversal study; circulating levels of resistin and adiponectin were measured by ELISA (RyDSystems Minneapolis) in 80 type-2 diabetic patients (40 normotensive and 40 hypertensive naïve to antihypertensive therapy), and in 40 normotensive non-diabetic subjects. Statistical analysis was performed with ANOVA.
Results: We found a non-significantly decreased levels of resistin in control group when compared with diabetic normotensive patients, (13.5 vs 16.7 ng/mL p › 0.05); however, the coexistence of hypertension increased significantly (25.9 ng/mL p‹ 0.005) those values. We also observed increased values of adiponectin in control group when compared with diabetic normotensive patients (9.6 vs 7.5 µg/mL, p‹0.05), but the coexistence of hypertension did not modified those values significantly (7.4 µg/dL p›0.05).
Conclusions: Diabetic patients have increased levels of resistin and lower values of adiponectin when compared with non diabetic subjects, coexistence of hypertension increase the levels of resistin but do not modified adiponectin values, this may explain why diabetic patients (hypertensive or not) had more complications than normotensive patients.
Rubio-Guerra AF, Cabrera-Miranda JL, Vargas-Robles H, Maceda-Serrano A, Lozano-Nuevo JJ, Escalante-Acosta BA. Correlation between Levels of circulating adipokines and adiponectin/resistin index with carotid intima-media thickness in hypertensive type 2 Diabetic Patients. Cardiology 2013;125:150-153.