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2014, Number 1

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Residente 2014; 9 (1)

Galectinas

González-Sánchez AG, Nava A

Language: Spanish
References: 8
Page: 9-14
PDF size: 310.47 Kb.


ABSTRACT

Galectins are proteins capable of recognizing lectin-carbohydrate complex macromolecules bound to it has a carbohydrate recognition domain (CRD). Fifteen subfamilies galectins exist in a variety of tissues of different species. The biological function of galectins will differ depending on which is expressed and ligand availability. Some functions related galectins are: regulating the immune response (lymphocyte adhesion, cytokines production and apoptosis), acute and chronic inflammation, allergic disorders, infections and neoplastic diseases. Galectins represent a potential and promising therapeutic agent, although further studies are required to elucidate the molecular mechanisms involved in their function.


REFERENCES

  1. Álvarez-Fernández G, Bustos-Jaimes I et al. Aspectos bioquímicos, estructurales y funcionales de las galectinas en la inmunidad. Mensaje Bioquímico. 2010; 34: 17-30.

  2. Rabinovich G, Rubinstein N. Galectinas: una nueva familia de proteínas involucradas en la regulación de la respuesta inmune. Medicina. 2001; 61: 85-92.

  3. Rabinovich G. Galectins: an evolutionary conserved family of animal lectins with multifunctional properties; a trip from the gene to clinical therapy. Cell Death Differ. 1999; 6: 711-721.

  4. Rabinovich G. Inmunopatología molecular: nuevas fronteras de la medicina: un nexo entre la investigación biomédica y la práctica clínica. Buenos Aires: Panamericana; 2004: pp. 151-161.

  5. Rabinovich G, Rubinstein N, Toscano M. Role of galectins in inflammatory and immunomodulatory processes. Biochim Biophys Acta. 2002; 1572: 274-284.

  6. Ortiz B. Galectina-1: regulador negativo de la respuesta inmune inflamatoria y posible agente terapéutico. Rev Inst Nal Enf Resp Mex. 2009; 22 (3): 206-2016.

  7. Demers M, Biron-Pain K. Galectina-7 in lymphoma: elevated expression in human lymphoid malignancies and decreased lymphoma dissemination by antisense strategies in experimental model. Cancer Res. 2007; 67: 2824-2829.

  8. Toscano MA, Bianco GA, Ilarregui JM et al. Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulate susceptibility to cell death. Nat Immunol. 2007; 8: 825-834.




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