Flores-Alatriste JD, Jacobo-Nájera S, Segura-Rodríguez R, Stern-Colín NJJ

Language: Spanish
References: 17
Page: 383-388
PDF size: 353.74 Kb.

ABSTRACT

Background: Inherited thrombophilia is a genetic tendency to suffer thrombotic events clinically evident at an early age, with frequent recurrences without apparent cause. In recent years thrombophilia has earned a place as a primary risk factor for abnormal pregnancy.
Objective: To determine the incidence of hereditary thrombophilia in patients with recurrent pregnancy loss.
Material and method: A retrospective, linear and descriptive study was conducted at Clinic of Reproduction IMMUNOREP with patients treated from January 2007 to December 2012. The study included patients with a diagnosis of recurrent pregnancy loss and inherited thrombophilia with laboratory studies of thrombophilia including different genes: G1619A (factor V Leiden), R2 H1299R (factor V polymorphism), C677T (methylenetetrahydrofolate reductase enzyme polymorphism), A1298C (methylenetetrahydrofolate reductase enzyme mutation), G20210A (mutation of the prothrombin gene), V34L (factor XIII polymorphism), 455G › A (fibrinogen gene mutation), 4G/5G (plasminogen activator inhibitor) and a/b L33P (ribosomal polymorphism of methylenetetrahydrofolate reductase enzyme).
Results: 211 files were reviewed and only 10.4% of patients were negative for hereditary thrombophilia, a percentage that is consistent with the results of different series of studies in patients with unexplained recurrent pregnancy loss. The most prevalent genetic condition was 4G/5G (plasminogen activator inhibitor, 85.5%) in homozygous and heterozygous with 63.4% (120) and 22.4% (42), respectively.
Conclusions: It was demonstrated the direct relationship between thrombophilia and recurrent pregnancy loss depending on whether the patient is heterozygous or homozygous for the disease.

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