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2014, Number 1

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Rev Mex Traspl 2014; 3 (1)

Induction therapy in renal transplantation: results of the Assessment Form and Transplant Registry (FERT) of Mexico

Morales-Buenrostro LE, Noyola-Villalobos HF, Alberú-Gómez J, Juárez-de la Cruz F, Gracida-Juárez C, Martínez-Mier G
Full text How to cite this article

Language: Spanish
References: 8
Page: 6-11
PDF size: 305.43 Kb.


Key words:

Induction therapy, kidney transplantation, IL2-RA, basiliximab.

ABSTRACT

Introduction: Created in Mexico during 2008, FERT (Evaluation and Transplant Registry Form) captured information from 36 kidney transplant centers during 1997-2008. We reviewed the use of induction therapy in renal transplantation in FERT. Methods: Data from participating centers were recorded. The following variables were captured: etiology of renal failure, donor type, and sex and age of both donors and recipients. Induction therapy and initial immunosuppressive therapy were recorded. Overall patient and graft survival, according to the type of induction, were evaluated. Results: 6,358 patients were collected. The average age of recipients was 32 ± 14 years and 59% of the recipients were male. The most common etiology of renal failure was of unknown origin in 57% of the cases. The average age of the donors was 36 ± 12 years, largely male (51%). Living donor transplant was most common (74.8%). 65.3% of transplant patients did not use induction therapy. The induction therapy (34.7%) most commonly used was basiliximab, in 18.2% of the cases. Conclusions: The results of the FERT study show that the use induction therapy during the period 1997-2008 was low compared with other international transplant registries. The induction therapy most common employed was basiliximab.


REFERENCES

  1. Centro Nacional de Trasplantes. 2014 [consultado el 15/01/14]. http://www.cenatra.salud.gob.mx

  2. Leppke S, Leighton T, Zaun D, et al. Scientific registry of transplant recipients: collecting, analyzing, and reporting data on transplantation in the United States. Transplant Rev (Orlando). 2013; 27 (2): 50-56.

  3. Opelz G, Döhler B, Ruhenstroth A, et al. The Collaborative Transplant Study registry. Transplant Rev (Orlando). 2013; 27 (2): 43-45.

  4. Noyola-Villalobos HF, Alberu-Gómez J, Gracida C, Morales-Buenrostro LE, Juárez-De la Cruz F, Martinez-Mier G et al. FERT results: results of the Collaborative Retrospective Study in Renal Transplantation in Mexico: 2586. Transplantation. 2010; 90 (2S): 926.

  5. Meier-Kriesche HU, Li S, Gruessner RWG, et al. Immunosuppression: evolution in practice and trends, 1994-2004. Am J Transplant. 2006; 6 (5p2): 1111-1131.

  6. Opelz G. President’s address. The Transplantation Society—Berlin 2012. Transplantation. 2013; 95 (1): 4-7.

  7. Collaborative Transplant Study. Graphics Archive. 2014 [consultado el 15/01/14]. http://www.ctstransplant.org/public/graphics/archive.shtml “CTS-K-33311-0210”

  8. Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group. KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Transplant. 2009; 9 (Suppl 3): S1-155.




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Rev Mex Traspl. 2014;3