Ley-Mandujano SS, Campos-Navarro LA

Language: Spanish
References: 11
Page: 165-170
PDF size: 323.99 Kb.

ABSTRACT

Background: The juvenile nasoangiofibroma is the commonest benign neoplasm of nasopharynx with malignant behavior. They represent 0.5% of tumors of the head and neck. In Mexico it has a high incidence, it represents a case in 5,000 ENT consultations. The juvenile nasoangiofibroma originate from vascular tissue. Microscopically is macroscomposed of fibrous stroma with vascular channels, without elastic fibers in the stroma, which predisposes to bleeding. One of the clinical manifestations epistaxis is threatening the live due to their magnitude and frequency, so it is of interest to find if there is one predominant histological pattern that justifies its clinical performance and correlation between the histological pattern and epistaxis.
Objective: To determine the histological pattern of juvenile nasoangiofibroma hospital patients attended at CMN La Raza.
Material and method: A retrospective study of surgical specimens of patients with juvenile nasoangiofibroma was performed from January 2008 to February 2010; angiomatous-fibrous features were identified and assessed the relationship between the frequency and intensity of epistaxis obtained from medical records.
Results: We studied 20 male patients with nasoangiofibroma; 55% (11 cases) between 13 and 16 years of age. The histopathology of fibrous mass was found, consisting of numerous new vessels with plump endothelium, mainly angiomatous pattern.
Conclusion: The predominant pattern of pathology is angiomatous angiofibroma. There is no association between histological and clinical characteristics or perioperative bleeding.

REFERENCES

1. Chavolla M, Chavolla C, Labra H. PAC otorrino-3. Tumores de nariz senos paranasales. 1ª ed. Intersistemas, 2002;15-30.

2. Escajadillo J. En: Tumores de nariz y senos paranasales. Oídos, nariz, garganta y cirugía de cabeza y cuello. 2ª ed. Manual Moderno, 2002;344-345.

3. Lee K. Otorrinolaringología pediátrica. En: Lee K, editor. Otorrinolaringología, cirugía de cabeza y cuello. 7ª ed. McGraw-Hill, 2002;967-968.

4. Krespi Y, Levine T. Tumores de la nariz y de los senos paranasales. En: Paparella MM, editor. Otorrinolaringología. 3ª ed. Panamericana, 1994;2280.

5. Fuente de información del Hospital general CMN La Raza. SIMO, 2008.

6. Jiangang L, Zixiang Y, Ping L. The nature of juvenile nasopharyngeal angiofibroma. Otolaryngol Head Neck Surg 2000;123:475-481.

7. Reséndiz N. Frecuencia de tumoraciones en la nariz y los senos paranasales en pacientes del servicio de otorrinolaringología del Hospital de Especialidades del Centro Médico Nacional Manuel Ávila Camacho. An Orl Mex 2006;51:14-16.

8. Arrieta J, Bross D, Prado H. Nasoangiofibroma: Conceptos actuales y revisión sobre su diagnóstico y tratamiento. Ann Med Asoc ABC 1997;42:79-83.

9. Bales C, Kotapka M, Loevner L. Craniofacial resection of advanced juvenile nasopharyngeal angiofibroma. Arch Otolaryngol Head Neck Surg 2002;128:1071-1078.

10. Shanmugaratnam K. The World Health Organization Histological classification of tumor of the upper respiratory tract. Cancer 1993;71:2689-2697.

11. Nagai M, Butugan O, Logullo A. Expression of growth factors, proto-oncogenes, and p53 in nasopharyngeal angiofibroma. Laryngoscope 1996;106:190-195.