González-Latapi P, Rodríguez-Violante M, Cervantes-Arriaga A, Calleja-Castillo JM, González-Aguilar A

Language: Spanish
References: 15
Page: 348-351
PDF size: 554.45 Kb.

ABSTRACT

Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDAR) is an autoimmune disorder characterized by neuropsychiatric symptoms, hyperkinetic movements, and even central hypoventilation. Anti-NMDAR encephalitis is a recently described disease, but is already considered one of the most frequent etiologies of noninfectious encephalitis. We report the case of 16-year-old man in which it the presence of anti-NMDAR antibodies in the absence of a neoplasm was identified. Disease course and gradual recovery, as well as a brief review of the syndrome, is presented. To our knowledge this is the first proven case of anti-NMDAR encephalitis in Mexico.

REFERENCES

1. Corsellis JA, Goldberg GJ, Norton AR. “Limbic encephalitis” and its association with carcinoma. Brain. 1968;91(3):481-96.

2. Buckley C, Oger J, Clover L, et al. Potassium channel antibodies in two patients with reversible limbic encephalitis. Ann Neurol. 2001;50(1):73-8.

3. Dalmau J, Tuzun E, Wu HY, et al. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol. 2007;61(1):25-36.

4. Lai M, Hughes EG, Peng X, et al. AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol. 2009;65(4):424-34.

5. Lancaster E, Lai M, Peng X, et al. Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol. 2010;9(1):67-76.

6. Lai M, Huijbers MG, Lancaster E, et al. Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol. 2010;9(8):776-85.

7. Ferioli S, Dalmau J, Kobet CA, Zhai QJ, Broderick JP, Espay AJ. Anti- N-methyl-D-aspartate receptor encephalitis: characteristic behavioral and movement disorder. Arch Neurol. 2010;67(2):250-1.

8. Labate A, Irani SR, Vincent A, et al. Anti-NMDA receptor encephalitis: a video case report. Epileptic Disord. 2009;11(3):267-9.

9. Irani SR, Bera K, Waters P, et al. N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain. 2010;133(Pt 6):1655-67.

10. Dalmau J, Lancaster E, Martínez-Hernández E, Rosenfeld MR, Balice- Gordon R. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol. 2011;10(1):63-74.

11. Seki M, Suzuki S, Iizuka T, et al. Neurological response to early removal of ovarian teratoma in anti-NMDAR encephalitis. J Neurol Neurosurg Psychiatry. 2008;79(3):324-6.

12. Shimazaki H, Morita M, Nakano I, Dalmau J. Inverse ocular bobbing in a patient with encephalitis associated with antibodies to the N-methyl- D-aspartate receptor. Arch Neurol. 2008;65(9):1251.

13. Dalmau J, Gleichman AJ, Hughes EG, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 2008;7(12):1091-8.

14. Schmitt SE, Pargeon K, Frechette ES, Hirsch LJ, Dalmau J, Friedman D. Extreme delta brush: A unique EEG pattern in adults with anti-NMDA receptor encephalitis. Neurology. 2012;79(11):1094-100.

15. Wandinger KP, Saschenbrecker S, Stoecker W, Dalmau J. Anti-NMDAreceptor encephalitis: a severe, multistage, treatable disorder presenting with psychosis. J Neuroimmunol. 2011;231(1-2):86-91.