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2014, Number 3

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Enf Infec Microbiol 2014; 34 (3)

Systemic inflammatory response syndrome in newborns of body weight below 1 500 grams

Ávila RR, Rangel García RA, Herrera PM, Camacho RRI, Velázquez QNI
Full text How to cite this article

Language: Spanish
References: 7
Page: 86-91
PDF size: 170.00 Kb.


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ABSTRACT

introduction. The physiological and laboratory variables and organ dysfunction are used to define the systemic inflammatory response syndrome (SIRS) which was amended at various stages of childhood, including term newborn. This study seeks to establish the utility of SIRS in neonates weighing ‹ 1 500 grams.
material and methods. Observational, prospective, analytical and comparative study of all preterm infants weighing › 1 500 grams. Maternal history were investigated and contrasted with infants or not met the definition of SIRS according to Goldstein et al.
results. Eighty five neonates were captured, 46 cases (54%) met the criteria for SIRS and 39 cases (46%) did not meet the criteria for SIRS. Significant background SIRS were associated with maternal chorioamnionitis, rupture of membranes › 18 hours and antenatal steroids. A significant factor associated with SIRS in neonates was less than 1 000 grams of weight, receiving parenteral nutrition for more than seven days and severe asphyxia. Blood culture was performed in 68/85 cases (80%), was positive in 17 (25%). It was statistically significant (p ‹ 0.001) and 22 times more infants in association with SIRS positive blood culture result.
conclusions. The scale of SIRS is useful in preterm infants because of the inherent exaggerated response to any inflammatory process.


REFERENCES

  1. Goldstein B, Giroir B, Randolph A, and the Members of the International Consensus Conference on Pediatric Sepsis. “International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics”, Pediatr Crit Care Med. 2005 ; 6: 2-8.

  2. Coronell W, Pérez C, Guerrero C,. Bustamante H. “Sepsis neonatal”. Revista de. Enfermedades Infecciosas en Pediatría 2009; 90: 57-68.

  3. Hofer N, Miiller W, Resch B. “(SIRS) definition and correlation withSystemic inflammatory response syndrom (SIRS) definition and correlation with early-onset bacterial infection of the newborn”. Arch Dis Child Fetal Neonatal Ed 2010 95: F151.

  4. Hofer N, Zacharias E , Müller W, Resch B. “Performance of the definitions of the systemic infl amatory response syndrome and sepsis in neonates”. J. Perinat. Med. 2012; 40: 587–590.

  5. Piantino J, Sc horaseiber M, Alexander K, Hageman J. “Culture Negative Sepsis and Systemic Inflammatory Response Syndrome in Neonates”. Neoreviews 2013;14;e294.

  6. Henneke P, Berner R. “SIRS and group-B streptococcal sepsis in newborns: Pathogenesis and perspectives in adjunctive therapy”, Seminars in Fetal & Neonatal Medicine. 2006; 11: 333e-342.

  7. Hofer N, Miiller W. “Systemic inflammatory response syndrome (SIRS) definition and correlation with early- onset bacterial infection of the newborn”. Arch Dis Child Fetal Neonatal. 2010; 95: F151.




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C?MO CITAR (Vancouver)

Enf Infec Microbiol. 2014;34