Cruz-Hernández V, León-Tapia S, Santos-Blas Y, Acevedo-Cruz A, Pérez CE

Language: Spanish
References: 15
Page: 496-501
PDF size: 376.35 Kb.

ABSTRACT

Thrombotic thrombocytopenic purpura belongs to the group of microangiopathic hemolytic anemia; it is characterized by fragmentation of erythrocytes and consumption of platetes. It is a very rare disease and its diagnosis is based on a pentad of symptoms: anemia, thrombocytopenia, fever, neurological abnormalities and kidney damage. This paper reviews five cases of thrombotic thrombocytopenic purpura treated in the area of Internal Medicine of the General Hospital Dr. Aurelio Valdivieso in the city of Oaxaca, Mexico, in a period of four years (April 2010 to March 2013), of which two met criteria to be considered as having refractory thrombotic thrombocytopenic purpura, one female and one male, aged 20 and 55 years old, respectively, both of them with idiopathic etiology. It is reviewed the therapeutic response to rituximab in these two patients with refractory thrombotic thrombocytopenic purpura, who had been treated in a conventional manner (steroids + plasma exchange) for seven days without adequate response.

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