2014, Number 5
Pharmacovigilance: Main therapeutic groups causing adverse reactions in patients attending to Regional Hospital Lic. Adolfo Lopez Mateos, Mexico City
González-Jiménez B, Estrada-Hernández LO
Full text
Language: Spanish
References: 11
Page: 520-530
PDF size: 872.24 Kb.
ABSTRACT
Background: In order to a drug be approved it must assure its secure and efficacy, by preclinic and clinic trials; the last ones involve human models with the aim to indentify, among others, adverse drug reactions. One important limitation of these trials is its population size, compared with population size that actually is going to take the drug.Objectives: To detect, notify, register and assess adverse drug reactions in order to determine the frequency, some predisposing factors and most frequent therapeutic groups as causal of adverse reactions.
Material and method: A retrospective study was performed usin pharmacovigilance and collected relevant information in order to identify major therapeutic groups, as well as predisposing factors (gender and age) in patients attending to Hospital Regional Lic. Adolfo Lopez Mateos, Mexico City. Codification of adverse reactions was made according to suggested by National Center of Pharmacovigilance, consisting on five fields. Notifications were compiled to extract information of therapeutic groups, number of cases of adverse reactions and drugs causing them.
Results: Main therapeutics groups were antibiotics, antiretroviral and analgesic drugs. Male gender showed the highest number of adverse drug reactions; mean age of studied population was of 30-39 years.
Conclusions: By assessing notifications of adverse reactions to drugs the main therapeutic groups causing these reactions were detected: antibiotic, antirretroviral and analgesic; thus, this study contributes to health professionals and patients to control properly the administration of drugs.
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