Martínez CYM, Sarduy NMR, Rodríguez ML

Language: Spanish
References: 18
Page:
PDF size: 160.61 Kb.

ABSTRACT

Adolescence is the transitional stage between childhood and adulthood, and is marked by changes, physical, emotional, psychological and social. It includes ranges from 10 to 19 years. The biology of the cervix, prolapse of endocervical mucosa occurs by enlargement of the cervix by the action of sex hormones. The physiological ectropion is most vulnerable and comes with histocytological squamous metaplastic epithelium abnormalities. Factors associated with HPV to develop cervical intraepithelial lesions, are early onset of sexual intercourse, multiple sexual partners, multiparity, smoking, sexually transmitted infections, the vitamin deficiency, some hormonal factors and the exogenous or endogenous immunodeficiency. Early initiation of sexual intercourse and sexual risk behavior are important factors in the development of intraepithelial lesions of the cervix that may develop into an invasive cancer. Over 80% of the LEI-BG and 100% of LEI- AG are associated with high-risk HPV. The diagnosis is made by organic cytology, colposcopy and histology. Cervical cancer is highly preventable and treatment should be limited to women with high-grade intraepithelial lesions as most cases of low grade or progress spontaneously normalized. Surgical therapy should be analyzed to make personalized and meet the specific information required by each adolescent.

REFERENCES

1. 1- Martínez Chang Y, Sarduy Nápoles M. Manejo de las adolescentes con neoplasia intraepitelial cervical Rev Cubana Invest Bioméd v.25 n.1 Ciudad de la Habana ene.-mar. 2006.

2. 2- Peláez Mendoza J.: Adolescencia y juventud. Desafíos actuales. Editorial Científico Técnica. La Habana, 2003 Cap I. p 3-14

3. 3- Peláez Mendoza, J. Ginecología pediátrica y de la adolescente. Editorial Científico Técnica. La Habana, 2007 p 31,183-192.

4. 4- Dávila H., García A., Álvarez F., Castillo Y., Imengana L., Matos Z.: Neoplasia intraepitelial de cuello uterino en un área de salud de la Isla de la Juventud, Cuba: 1999- 2008. Rev Chil Obstet Ginecol 2011; 76(4): 236 – 243.

5. 5- Programa integral para el control del cáncer en Cuba. Consenso de Radiocirugía en el tracto genital inferior. Edit. Ciencias Médicas. La Habana, 2011.Cap 10 p 27, 28

6. 6- Cabezas E.: Edad al inicio de las relaciones sexuales y carcinoma de cuello uterino. Rev Cubana Obstet Ginecol 2005; 11(1):97-104.

7. 7- Vizcaíno MJ., Herruzo R., Bilbao R., de Armas A., García A.: Factores de riesgo asociados a neoplasia intraepitelial cervical mediante un estudio de casos y controles. Clin Invest Ginecol Obstet. 2000; 27: 324-8.

8. 8- American College of Obstetricians and Gynecologists. Cervical cancer in adolescents: screening, evaluation, and management. Committee Opinion No. 463. Obstet Gynecol. 2010; 116: 469–72.

9. 9- Kahn JA.: HPV vaccination for the prevention of cervical intraepithelial neoplasia. N Engl J Med. 2009; 361:271-278

10. 10- León G., Arango M., Faxas M.: Respuesta inmune celular en pacientes con lesiones benignas y malignas del cuello uterino. Rev Cubana Obstet Ginecol vol.37 no.4 Ciudad de la Habana oct.-dic. 2011

11. 11- Sarduy M., Martínez Y. M., Vasallo R., Armas M.C., Sabatier C.A., Herrera B.: Lesiones intraepiteliales cervicales de bajo grado. Regresión, persistencia y progresión a los dos años de evolución. Rev Cubana Obstet Ginecol v.35 n.3 Ciudad de la Habana jul.-sep. 2009

12. 12- Sarduy Nápoles M.: Evaluación de tres métodos de tratamiento conservador de la Neoplasia Intraepitelial Cervical. Tesis doctoral. CIMEQ, La Habana. 2006.

13. 13- Purnima B, Stephen R, Mattarollo C, Ian H.: Regulation of immune responses to HPV infection and during HPV directed. Immunotherapy Immunological Reviews. 2011; 239:85-98.

14. 14-Aguilar K., Ríos M.A., Hernández M., Aguilar F., Silveira M., Nápoles M.: Papiloma viral humano y cáncer de cuello uterino. Rev Cubana Obstet Ginecol v.34 n.1 Ciudad de la Habana ene.-abr. 2008

15. 15- Sellors W.: La colposcopía y el tratamiento de la neoplasia intraepitelial cervical: manual para principiantes. Cap 2 pág. 18. Washington, D.C.: OPS, © 2003.

16. 16- Sarduy M.: Correlación citohistológica en las neoplasias intraepiteliales cervicales e identificación del VPH en esas lesiones .Rev Cubana Obstet Ginecol v.35 n.1 Ciudad de la Habana ene.-mar. 2009.

17. 17- Hillemanns P, Wang X, Staehle S, Michels W, Dannecker C. Evaluation of different treatment modalities for vulvar intraepithelial neoplasia (VIN): CO2 laser vaporization, photodynamic therapy, excision and vulvectomy. Gynecol Oncol 2006; 100 (2): 271-5.

18. 18- Xavier Bosh F.: Control y prevención del cáncer del cuello uterino. Curso virtual. Modulo 5. Institut Catalá d ' Oncologia. http://www.aulaeoncologia.org/file.php/49/moddata/s corm/254/es/ico_vacunas_vuccnet_05_00/launch.htm/