Narváez-Hernández E, Méndez-Sánchez ER, Candolfi-Arballo O, Castillo-Martínez NA, Dávila-Lezama A, Cerón-Ramírez LM

Language: Spanish
References: 7
Page: 232-236
PDF size: 365.03 Kb.

ABSTRACT

Background: Yeasts in nasal cytology have not yet shown any clinical significance, some studies have considered nasal yeast saprophytic flora but its role in pathology is not yet understood.
Objective: To compare the presence of yeast in nasal cytology in patients with chronic rhinosinusitis vs healthy subjects.
Material and methods: A prospective study was done in which sample smears were taken to asymptomatic subjects and patients with chronic rhinosinusitis (nasal obstruction/congestion; secretion: anterior/posterior rhinorrhea; sore/facial pressure sensation; complete or partial loss of consciousness of smell) within a period not lesser than 12 weeks. We excluded smokers, minors and those who applied intranasal drugs or other substances. We studied the presence of yeast, lymphocytes, eosinophils and bacteria by Wright stain. All samples where inoculated in Chromagar and Sabouraud cultures.
Results: The study included 60 subjects: 30 asymptomatic (control group) and 30 patients with chronic rhinosinusitis (study group). The study in control group showed no yeast, eosinophilia was observed in only 2 (6.6%) smears accompanied with lymphocytosis. In the group of chronic rhinosinusitis were observed yeast in a total of 11 patients (36.6%) of which: 8 smears with yeast and eosinophilia (72.7%) and 3 smears (27.3%) with yeast, eosinophilia and lymphocytosis.
Conclusions: There is a significant difference between the control group and the chronic rhinosinusitis group (p = 0.001); it is required further study of the behavior of yeasts in patients with rhinosinusitis as these may contribute to the chronicity of symptoms. These results conclude the need for larger population study to complement the findings of this work.

REFERENCES

1. Stuttgart. Rhinologic diagnosis and treatment. 1st ed. Estados Unidos de América: Thieme, 1997;193-212.

2. Fedorovskaia EA, Rybal’skaia AP, Skachkova NK, Mel’nik EA, et al. Characteristic of the yeast isolated from patients with leukaemia. Mikrobiol Z 2008;70:18-24.

3. Canakcioglu S, Tahamiler R, Saritzali G, Alimoglu Y. Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study. Am J Otolaryngol Head Neck Surg 2009;30:312-317.

4. Norbäck D, Wĺlinder R, Wieslander G, Smedje G, et al. Indoor air pollutants in schools: nasal patency and biomarkers in nasal lavage. Allergy 2008;55:163-170.

5. Soler ZM, Schlosser RJ. The role of fungi in diseases of the nose and sinuses. Am J Rhinol Allergy 2012;26:351-358.

6. Ozgür A, Arslanoğlu S, Etıt D, Demıray U, Onal HK. Comparison of nasal cytology and symptom scores in patients with seasonal allergic rhinitis, before and after treatment. J Laryngol Otol 2011;27:1-5.

7. Liu CM, Soldanova K, Nordstrom L, Dwan MG, et al. Medical therapy reduces microbiota diversity and evenness in surgically recalcitrant chronic rhinosinusitis. Int Forum Allergy Rhinol 2013;10:775-781.