Ornelas-Casillas MA, López-Buenrostro SA

Language: Spanish
References: 6
Page: 84-87
PDF size: 659.54 Kb.

ABSTRACT

Rasmussen syndrome is an autoimmune encephalitis characterized by continuous partial seizures of difficult control and aphasia. Evidence shows that the autoimmune component of the disease relies on the existence of auto antibodies against subunit 3 of the glutamate receptor (Glu3). There is also a causal association with viral infections; most of them are part of the herpes virus family, like citomegalovirus (CMV) and Epstein-Barr Virus (EBV).
Due to resistance to antiepileptic drugs, management with immunoglobulin shows slower progression of the disease and clinical improvement in most patients. Despite the benefits shown with immunoglobulin, the only therapeutic strategy that has shown better results is hemispherectomy.
We present the case of a 2-year-old girl with seizures after suffering traumatic brain injury. She experienced tonicclonic seizures on the right side of the body with poor response to anti-seizure medications. Magnetic resonance imaging and electroencephalography revealed characteristics that suggested this disease. The patient underwent right frontotemporal lobectomy and biopsies confirmed the Rasmussen Syndrome diagnosis.

REFERENCES

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