Guevara CRM, Quintos RAI, Alfaro MA, Quiñonez UE, Quintal RMJ, Lara TH, López IMM

Language: Spanish
References: 12
Page: 193-198
PDF size: 346.64 Kb.

ABSTRACT

Malignant acanthosis nigricans is paraneoplastic syndrome of unknown etiology, characterized by the presence of plaques and papillomatous hyperpigmentation. It is related to intra-abdominal tumors in 94% of cases of which, 61-69% are concomitant with gastric adenocarcinoma, although it is also present in other malignancies including acute myeloid leukemia, lymphoma, and bladder or liver carcinoma. Existing literature reports only one case of MAN secondary to lung and prostate cancer.
This entity may coexist with three other paraneoplastic syndromes: 1) tripe palms (pachydermatoglyphia), 2) Leser-Trélat sign, and 3) florid cutaneous papillomatosis. Treatment involves tumor removal. Persistence or reappearance of skin lesions suggests hidden recurrence or metastasis.
This is a case report of a patient presenting malignant acanthosis nigricans, tripe palms and florid cutaneous papillomatosis in association with prostate cancer.

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