Human leukocyte antigen is a class I HLA classic molecule that is preferentially expressed in cytotrophoblast cells and participates in tolerance and immune system suppression. The expression of HLA-G is induced in viral infections, autoimmune disorders,

Ángela Porras-Dorantes; José Elías García-Ortiz

2014, Number S2

Next >>

Gac Med Mex 2014; 150 (S2)

Human leukocyte antigen is a class I HLA classic molecule that is preferentially expressed in cytotrophoblast cells and participates in tolerance and immune system suppression. The expression of HLA-G is induced in viral infections, autoimmune disorders,

Porras-Dorantes Á, García-Ortiz JE

Full text

How to cite this article

Language: Spanish
References: 4
Page: 138-139
PDF size: 190.40 Kb.

ABSTRACT

Human leukocyte antigen is a class I HLA classic molecule that is preferentially expressed in cytotrophoblast cells and participates in tolerance and immune system suppression. The expression of HLA-G is induced in viral infections, autoimmune disorders, and cancers. Currently, HLA-G is considered a biomarker in the diagnosis, prognosis, and therapy of cancer.

REFERENCES

Yan WH. HLA-G expression in cancers: potential role in diagnosis, prognosis and therapy. Endocr Metab Immune Disord Drug Targets. 2011;11(1):76-89.
Curigliano G, Criscitiello C, Gelao L, Goldhirsch A. Molecular Pathways: Human leukocyte antigen G (HLA-G). Clin Cancer Res. 2013. [Epub ahead of print].
Amiot L, Ferrone S, Grosse-Wilde H, Seliger B. Biology of HLA-G in cancer: a candidate molecule for therapeutic intervention? Cell Mol Life Sci. 2011;68(3):417-31.
González A, Rebmann V, LeMaoult J, Horn PA, Carosella ED, Alegre E. The immunosuppressive molecule HLA-G and its clinical implications. Crit Rev Clin Lab Sci. 2012;49(3):63-84.