2012, Number 4
Dermatología Cosmética, Médica y Quirúrgica 2012; 10 (4)
León L, Cubilla E, Guzmán A, Mendoza G, Celias L, Arenas R, Benuto RE, Berumen J
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ABSTRACTThe multifocal epithelial hyperplasia (MEH), also known as focal epithelial hyperplasia, Heck disease or multifocal epithelial hyperplasia caused by papilloma virus is a proliferative disease of the oral mucosa, caused by the human papilloma virus (VPH) types 13 and 32. Factors involved in susceptibility and transmission are still unknown, but tendency to affect certain ethnic groups and familial cases suggest a genetic predisposition. A significant association between HLA DR4 and HLA – DRBI 0404, is relatively frequent in American Indians.
We report two cases in female adolescents, non-consanguineous, with papular or papilomatous lesions in oral mucosa compatible with HEM and VPH-13. A brief review of the literature is performed.