Sáenz CC, Fabián VMR, Garrido EX, Lozano-Platonoff A, Contreras RJ

Language: Spanish
References: 19
Page: 249-254
PDF size: 770.22 Kb.

ABSTRACT

Antecedents: Pressure ulcers (PU) are frequently seen in dermatologic clinics. There is lack of knowledge of the pathophysiology and proper treatment of these entities, and therefore there are multiple treatments, very few of which have been carefully evaluated. Hyaluronic acid is a wound matrix component, naturally existing in body tissues and, as it has been previously published, wounds will not heal in the presence of hypoalbuminemia. We present this study to evaluate the efficacy of hyaluronic acid in the treatment of stage III and IV pressure ulcers in patients with hypoalbuminemia.
Material and methods: Eight consecutive patients with pressure ulcers and hypoalbuminemia, who came to the Wound Healing Center, were treated with daily application of 0.2% hyaluronic acid cream for a period of maximum 6 weeks. The efficacy of the therapy was evaluated by wound measurements and the characteristics of pressure ulcers.
Results: The most frequent location of the ulcers was the sacrum. The average albumin levels were 2.2 g/dL (1.4 to 2.9). All patients responded favorably with wound size decrease. Most of the ulcers had more than 50% granulation tissue, except one that had 100% fibrin. At the end of the trial, all had more than 50% granulation. No side effects or contact dermatitis were observed.
Conclusions: In this series of 8 patients, 2% hyaluronic acid cream was effective in the treatment of stages III and IV pressure ulcers in the presence of hypoalbuminemia.

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