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2005, Number 3

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Dermatología Cosmética, Médica y Quirúrgica 2005; 3 (3)

Mammary Paget’s disease: Up to date

Káram OM, Vera ID, Vega MME

Language: Spanish
References: 25
Page: 286-290
PDF size: 354.14 Kb.


ABSTRACT

Paget’s disease of the nipple is a superficial manifestation of an underlying breast malignancy; it was described in 1874 by sir James Paget. It has been reported in 1-3% of all breast carcinoma. The peak incidence is between 50 and 60 years. Clinically appears as a unilateral, erythematous, scaly plaque slightly infiltrated; retraction of the nipple and serosanguinous discharge may be present. A biopsy is mandatory for the diagnosis. The histologic hallmark, the Paget’s cells, described as a large ovoid intraepidermal cell with abundant pale cytoplasma. The most common presentation is with intraductal carcinoma. Radical mastectomy, radiation and close surveillance are appropriate therapies. Patients without palpable mass have a better prognosis.


REFERENCES

  1. Whitaker-Worth L, Carlone V, Susser N et al. Dermatologic diseases of the breast and nipple. J Am Acad Dermatol 2000;43:733-751

  2. Osther P, Balslev E, Blichert M. Paget’s disease of the nipple: a continuing enigma. Acta Chir Scand 1990;156:343-352

  3. Du Toit RS, Van Rensburg P, Goedhals L. Paget’s disease of the breast. S Afr Med J 1988; 73: 95

  4. Menzies D, Barr L, Ellis H. Paget’s disease of the nipple occurring after wide local excision and radiotherapy for carcinoma of the breast. Eur J Surg Oncol 1989; 15: 271

  5. Gupta S, Khanna N, Khanna S. Paget’s disease of the male breast: A clinicopathologic study and a collective review. J Surg Oncol 1983; 22: 151

  6. Serour F, Brikenfeld S, Amsterdam E et al. Paget’s disease of the male breast. Cancer 1988; 62: 601

  7. Muir R. The pathogenesis of Paget’s disease of the nipple and associated lesions. Br J Surg 1935; 22: 728-737

  8. Sagebiel RW. Ultrastructural observations on epidermal cells in Paget’s disese of the breast. Am J Pathol 1969; 53: 40-64

  9. Schelfhout VR, Coene Ed, Delaey B et al. Pathogenesis of Paget’s disease: epidermal heregulin-alpha, motility factor, and the HER receptor family. J Natl Cancer Inst 2000; 92 (8): 622-628.

  10. Ascensao AC, Marques MSJ, Capitao-Mor M. Paget’s disease of the breast. S Afr Med J 1988 73: 95

  11. Ikeda DM, Helvie MA, Frank TS et al. Paget’s disease of the nipple: Radiologic-pathologic correlation. Radiology 1993;189:89.

  12. Kollmorgen D, Varanasi J, Edge S et al. Paget’s disease of the breast: a 33-year experience. J Am Coll Surg 1998;187:171-177.

  13. Jones RE Jr. Mammary Paget’s disease without underlying carcinoma. Am J Dermatopathol 1985;7:361-5

  14. Yim J, Wick M, Philpott G et al. Underlying pathology in mammary Paget’s disease. Ann Surg Oncol 1997; 4: 287-292

  15. Cheatle GL & Cutler M. Paget’s disease of the nipple. Arch Pathol 1931; 12: 435

  16. Muir R. Further observations on Paget’s disease of the nipple and associated lesions. J Pathol 1939; 49: 299

  17. Lundquist K, Kohler S, Rouse RV. Intraepidermal cytokeratin 7 expression is not restricted to Paget cells but is also seen in Toker cells and Merkel cells. Am J Surg Pathol 1999; 23 (2): 212-219

  18. Faek R, Ricci A, Deckers P. Paget’s disease of the nipple-areola complex. Surgical Clinics of North America 1996;76(2) 365-381

  19. Osteen R. Paget’s disease of the nipple. Breast Disease 1991: 797-803

  20. Lucarotti K, Dunn JM, Webb AJ. Scrape cytology in the diagnosis of Paget’s disease of the breast. Cytopathology 1994; 5 (5) 301-305

  21. Ashikari R, Park K, Huvos AG et al. Paget’s disease of the breast. Cancer 1970; 26: 680

  22. Chaudary MA, Mills RR, Lane B et al. Paget’s disease of the nipple: A ten year review including clinical, pathological, and immunolhitochemical findings. Breast Cancer Res Treat 1986; 8: 139

  23. Eusebio RB & Deckers PJ. Paget’s disease of the nipple-areola complex: A plea for conservatism. Contem Surg 1992: 40: 13

  24. Dixon AR, Galea MH, Ellis IO et al. Paget’s disease of the nipple. Br J Surg 1991; 78: 722

  25. Fourquet A, Campana F, Vielh P et al. Paget’s disease of the nipple without detectable breast tumor: Conservative management with radiation therapy. Int J Radiat Oncol Biol Phys 1987; 13: 146




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