Santos-Juanes J, Palomo C, Galache C, Costas C, Curto JR, Sánchez RJ, Menéndez P, Ribas A, Soto J

Language: Spanish
References: 18
Page: 187-191
PDF size: 365.02 Kb.

ABSTRACT

Anaplastic large cell lymphoma is a high-grade non-Hodgkin´s lymphoma recognized by the expression of the CD30 marker and by its morphology. There are two major groups: the primary cutaneous and the systemic nodal, the most common form.
We report a man who developed tchy lesions over the trunk. Physical examination showed hiperkeratotic macules over the extremities and trunk, and a infiltrated cervical tumor. The skin biopsy showed a ichthyosis acquisita and the cervical mass biopsy showed a ganglionar anaplastic large cell lymphoma, with extraganglionar spread.
Ichthyosis acquisita is a paraneoplastic syndrome rarely observed in patients with malignant diseases, it has been recognized in lymphoproliferative malignancies. This is the five case report of acquired ichthyosis associated with anaplastic large-cell lymphoma.

REFERENCES

1. Tilly H, Gaulard P, Lepage E, Dumontet C, Diebold J, Plantier I, et al. Primary anaplastic large-cell lymphoma in adults: clínical presentation, immunophenotype, and outcome. Blood 1997;90: 3727-3734.

2. Kato N, Yasukawa K, Kimura K, Yoshida K. Anaplastic large-cell lymphoma associated with acquired ichthyosis. J Am Acad Dermatol 2000;42:914-920.

3. Kato N, Mizunu O, Ito K, Kimura K, Shimata M. Neutrophil-rich anaplatic large cell lymphoma presentig in the skin. Am J Dermatopathol 2003;25:142-147.

4. Zamolo G, Gruber F, Bosner A, Cabrijan L, Petkovi´c M, Jonji´c N. CD30-Positive cutaneous anaplastic large cell lymphoma with ichthyosis acquisita. Tumori 1999;85: 71-74.

5. Virgili A., Corazza M., Lombardi A.R., Altieri E.: Ittiosi acquisita associata a linfoma anaplastico a grandi cellule Ki-1+. G Ital Dermatol Venereol, 1995;130:147-150.

6. Kaplinsky C, Toren A, Neumann Y, Mandel M, Kenet G, Sharon N, et al. Central nervous system involvement at diagnosis in a case of pediatric CD30+ anaplastic large cell lymphoma. Med Pediatr Oncol 1997;28:132-135.

7. Banerje SS, Heald J, Harris. Twelve cases of Ki-1 positive anaplastic large cell lymphoma of skin. J Clin Pathol 1991;44:119-125.

8. Kadin ME: Primary Ki-1-positive anaplastic large-cell lymphoma: A distinct clinicopathologic entity. Ann Oncol, 1994;5:25.

9. Berge RL, Oudejans JJ, Ossenkoppele GJ, Meijer CJLM. ALKs-negative systemic anaplastic large cell lymphoma: differential diagnostic and prognostic aspects-a review. J Pathol 2003;200:4-15.

10. Kadin ME: The spectrum of Ki-1+ cutaneous lymphoma. Curr Probl Dermatol, 1990;19:132.

11. Feller AC, Sterry W. Large anaplastic lymphoma of the skin. Br J Dermatol 1989;121:593.

12. Nakamura S, Shiota M, Nakagawa A, Yotabe Y, Kojima M, Motoori, et al. Anaplastic large cell lymphoma: a distintic molecular pathologic entity: a reappraisal with special reference tu p80 NPK/ALK expresion. Am J Surg Pathol 1997;21:1420-1432.

13. Kaudewitz P, Stein H, Dallenbach F, Eckert F, Bieber K, Burg G, Braun-falco O: Primary and secondary cutaneous ki-1+ (CD 30+) anaplastic large cell lymphomas. Morphologic, immunohistologic and clinical characteristics. Am J Pathol, 1989;135:359-367.

14. Dykes PJ, Marks R. Acquired icthyosis multiple causes for an acquired generalized disturbance in desquamation. Br J Dermatol 1977;97:327-334.

15. Cohen PR, Kurzrock R. Mucocutaneous paraneoplastic syndromes. Semin Oncol 1997;24:334-359.

16. Litoux P, Stalder J, Dreno B. Dermatoses paranéoplasiques. -Editions Techniques- Encycl. Méd. Chir. (Paris-France), Dermatolologie, 12-575-A-10, 1994, 8p.

17. Kurzrock R, Cohen PR. Mucocutaneous paraneoplastic manifestations of hematologic malignancies. Am J Med 1995;99:207-216.

18. Curth HO: Skin lesions and internal carcinoma. In: Cancer of the Skin (Andrade R, Gumport SL, Popkin GL et al. eds.). WB Saunders, 1976;1308-1341