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2015, Number 2

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Rev Mex Patol Clin Med Lab 2015; 62 (2)

Estimation of LDL cholesterol through the Brazilian equation: comparison to other methodologies

Querales M, Domínguez MI, Rojas S

Language: Spanish
References: 16
Page: 91-96
PDF size: 250.07 Kb.


ABSTRACT

Introduction: A Brazilian equation for the estimation of the low-density lipoprotein cholesterol (LDL-c) was recently proposed, with few studies employing it in the rest of Latin America. Objective: To use the Brazilian equation in Venezuelan patients and compare its results with other methodologies. Material and methods: LDL-c serum levels were measured in 98 patients through the Brazilian equation and other three methodologies: Friedewald formula, precipitation and computerized direct method technique. Results: The values obtained by the Brazilian equation represented data with less dispersion and equivalent to the direct methodology, being inferior to the other methodologies, especially in the triglyceride ranges lower than 151 and greater than 200 mg/dL. The number of patients classified with a low, medium and high cardiovascular risk was statistically equal among the Brazilian equation and the direct method, with variations to the Friedewald formula and the technique of precipitation. Conclusions: The Brazilian equation and the direct method are equivalent, generating lower values than the Friedewald formula and the precipitation technique. The application of this equation in clinical laboratories for routine calculation of LDL-c is recommended.


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