2015, Number 2
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Rev Mex Patol Clin Med Lab 2015; 62 (2)
Urinary excretion of a substance predicted from the substance-creatinine index
Salabarría GJR, Santana PS, Liriano RMR
Language: Spanish
References: 23
Page: 119-126
PDF size: 384.41 Kb.
ABSTRACT
Introduction: C
sust/OCre index can be an alternative method for measuring urinary excretion of a substance.
Objective: To assess the analytical and clinical usefulness of the prediction of the urinary excretion of a substance from its C
sust/OCre index.
Material and methods: From the records of the Laboratory for the Study of Kidney Function, Clinical Laboratory Service, the concentration values of creatinine (OCre) and the substance of interest (C
sust; with sust: total proteins, albumin, calcium, magnesium or uric acid) were measured in urine samples of children and adolescents of either sex, ages between 1 and 19 years, treated at the «Juan Manuel Márquez» Teaching University Hospital (Havana City, Cuba) between 2009 and 2014. Urinary excretion of the substance was estimated from the C
sust/OCre ratio, after adjusting for creatinine expected as per Schwartz et al. (1973).
Results: Ensuring correct 24-hour urine collection, average excretion values for a specified substance were similar to the observed ones; and urinary excretion values returned by either of the calculation strategies were equivalent throughout the whole range of interest (being analytical accuracy ≥ 85%); for the same frequency of abnormal values.
Conclusion: C
sust/OCre index might serve to predict the quantity of a substance to be excreted during 24 hours in a subject’s life.
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