Diez GMP, Chávez AD, Mercado CR, Domínguez HVM, Torres MA, Lomelí MPA, Méndez HJ

Language: Spanish
References: 19
Page: 113-117
PDF size: 49.87 Kb.

ABSTRACT

Introduction. This is an experimental model of osseous fracture and fracture healing, which begins with the design and manufacture of a machine to produce standard fractures (Brighton and Landry, 1996). Material and methods. The study of 25 male Wistar rats 300-450 g of weight, managed for tibial shaft fracture and intramedullary nail. Biochemical evaluation: Na+ K+ Ca+ P. Biomechanics: Bending strength, yield point, stiffness, absorbed energy. Histological study (pathology). Results. There were 2 transversal fractures, 22 short oblique, 1 multifragmentary; Bending strength, yield point 103.8 ± 28.9 N. Observe increase of (CaNaPKMg) with a maximum at approximately 15 days. Sacrify rats: at 3 days, osseous material on edge, minimum granulation, inflammatory cells; 7 days: hemorrhage hyperplasia on margins, osteoblasts, immature cartilage; 13 days: osseous tissue, bridge of periosteum and endosteum, immature cartilage cells, new bone; 21 days: healing of fracture days complete fracture healing. Statistics. Student´s t test, ANOVA. Discussion. The model has been repeated in 25 rats, fracture at 80% of energy (transverse and short oblique fractures), bone absorbs more energy than intramedullary nail. Histological study has normal process of osseous growth on the induction stage; formation of soft callus, hard and remodelation, agree with the sanguineus increase (Na Ca P K Mg). Conclusion. It is possible to have an experimental model of fracture production and bone fracture healing.

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