Pérez-Beltrán CF, Garza-Zúñiga MJ, Isaías-Camacho JO, Andrade-Carmona V, Díaz-Greene EJ, Rodríguez-Weber FL

Language: Spanish
References: 0
Page: 324-336
PDF size: 475.97 Kb.

ABSTRACT

Vasculitis is a group of diseases of unknown etiology, whose main characteristic is the gradual occlusion of the arterial lumen to a total occlusion of the same, which affects a variety of organs, that include lungs, kidneys, skin and brain, among others. Its pathophysiology is partially known; however, it is known that there is a disturbance of the immune system in which autoantibodies are produced, many of them are directed against multiple antigens located in the walls of blood vessels. Main autoantibodies produced are the ANCAs (antineutrophil cytoplasmic antibodies). Their role is mainly an indication in the diagnosis of this disease because it allows classifying positive (Wegener’s granulomatosis, Churg-Strauss syndrome and microscopic polyangiitis) and negative ANCA vasculitis (Henoch-Schönlein purpura, cryoglobulinemic vasculitis, Kawasaki disease, Takayasu’s arteritis and temporal arteritis).