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2003, Number 4

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Dermatología Cosmética, Médica y Quirúrgica 2003; 1 (4)

Isotretinoin

Saúl A

Language: Spanish
References: 8
Page: 218-220
PDF size: 81.52 Kb.


ABSTRACT

Isotretinoin is a synthetic retinoid that interacts with the specific receptors of the retinoic acid. It reduces the size of the sebaceous gland, with a significance decrease in the sebaceous secretion and the cellular adhesion eliminating the follicular plugs and as a consequence also the formation of comedons. It could be the ideal drug because it has the following actions: Antiseborrheic, keratolytic, and also with an indirect effect on P. acnes and in the inflammation.
It is indicated mainly in acne conglobata, fulminans and nodulocystic or in papulo-pustular resistant to the traditional treatment; other indications are rosacea, demodecidosis, gram-negative folicullitis and pyoderma facial. The recommended dose is 0.5 to 1 mg/kg of body weight, till a total dose of 120 to 150 mg/kg, which is usually achieved in 4 to 6 months. The common adverse effects are xeroderma, xerosthomia, xerophthalmia and cheilits. The teratogenic effect is the most important one, but it also has interactions with drugs such as vitamin A, tetracyclines, carbamazepine, and alcohol.


REFERENCES

  1. Silva-Siwady JG. La isotretinoína oral en el paciente con acné. Dermatología Rev Mex 1995; 39 (3): 154-158

  2. Orfanos CE, Zouboulis CH. Oral retinoids en the treatment of seborrhoea and acne. Dermatology 1998; 196: 140-147

  3. Bigby M, Stern RS. Adverse reactions to isotretinoin. J Am Ac Dermatol. 1988; 18: 543-552

  4. Strauss JS, Rapini RP, Shalita AR et al. Isotretinoin therapy for acne. Results of a multicenter dose-response study. J Am Ac Dermatol 1984; 10: 490-496

  5. Saúl A. Lecciones de dermatología. 14a ed. México: Méndez Editores, 2001: 515-534

  6. Jick SS, Maraqdi KH, Vasilokis SC. Isotretinoin. Use and risk of depression psychotic symptoms, suicide and attempted suicide. Arch Dermatol 2000; 136: 1231

  7. Ellis ChN, Krach KJ. Isotretinoin. A state of the art conference. Uses and complications of isotretinoin therapy. J Am Acad Dermatol 2001; 45 (5): S150-157

  8. Chan A, Hanna M, Abbott M, Keane RJ. Oral retinoids and pregnancy. MJA 1996; 165: 164-167




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