2002, Number 5
Effect of the immunostimulation in the traumatized patient
Ramírez AJA, Rojas MJG, Jiménez STP, Sarmiento HAP, Murillo NFJ
Full text
Language: Spanish
References: 14
Page: 253-257
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ABSTRACT
In Mexico, death by accidents occupies the second place as cause of death. After a serious traumatism, major surgery, collision or sepsis, a series of actions (metabolic answer to trauma) are presented and they largely determine the lifespan possibility before serious stress. Some studies show a discreet but constant decrease of the immune answer, manifested by an initial increase and later a decrease of the T4, T8 and NK lymphocytes. It is also shown that alterations in the phagocytosis exist, mainly in the patients with smaller grade fractures and in the patients with craniocephalic traumatism. This indicates that the immune deterioration is different according to the type of damage, but it is always present in the traumatized patients. The objective of the present study is to analyze the effects of the immune stimulation with glycophosphopeptical GB-100 in the evolution of traumatized patients. They formed three groups: (1) patient with exposed fracture of long bones, (2) with craniocephalic traumatism and (3) with penetrating wound of the thorax and/or the abdomen. They administered GB-100 as a randomized, double blind placebo-controlled clinical trial, and their hematic biometry, hemoglobin, hematocrit, phagocytic index and the generation of radical cytocides of the oxygen was determined, as well as the hospital stay. Prior consent informed according to the Helsinki protocol, they took samples of blood for the analyses mentioned. The results show that with the immune modulation, in the three groups the cells with maximum phagocytic activity increased up to 300; concomitantly those with null activity in 50% diminish. The leukocytes maintain a normal concentration, while with placebo there is a persistent leukocytosis. The hospital stay was diminished by 50% in the three groups treated with immune stimulant. The levels of Hb and Ht showed no changes, but the platelets rose in the three groups. These data show that the GB-100 improves the phagocytosis, it normalizes the count of leukocytes and it increases the number of platelets in the traumatized patients. The main effects are the reduction in the time of hospital stay that reaches up to 50% and the evolution without incidents.REFERENCES