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Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio

2002, Number 2

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Rev Mex Patol Clin Med Lab 2002; 49 (2)

Evaluation of the impact of lactose intolerance in the osteoporosis risk

Terrés-Speziale AM, Casas TLT

Language: Spanish
References: 16
Page: 77-84
PDF size: 234.86 Kb.


ABSTRACT

Background: Osteoporosis (OP) is a chronic degenerative condition that weakens bones while increasing chances of column, hip and forearm fractures. Lactose intolerance (LI) is a disease characterized by several clinical symptoms including diarrhea after milk intake, causing a reduction on dairy consumption. Objective: To study a cohort of adult healthy females, in order to establish lactose intolerance frequency, symptoms, milk consumption, and to determine existent relation among lactose intolerance and several osteoporosis risk factors. 1. BMI: Body mass index (kg/m2); 2. BDM: Bone densitometry, 3. UBM: Urinary bone markers. Method: Clinical, prospective, observational, descriptive and comparative protocol on a cohort of women attended for preventive medical evaluation on a specialized osteoporosis clinic during the first trimester of 2002. Results: One hundred and forty one women were evaluated with an age range of 36 to 65 years. Lactose intolerance was found on 22%; this group consumes less milk products (12%) and food supplements (7%) than the milk digesters group. No difference was found on BMI (kg/m2). Patients with lactose intolerance have a shorter bone calcium reserve and a slower bone remodeling activity, since they had a deeper T-Score on densitometry (p ‹ 0.05) plus a smaller calciuria (p › 0.05), with less urinary N-Telopeptides (p ‹ 0.05). This phenomenon, on lactase intolerance patients may well be explained through a compensatory homeostatic mechanism in order to maintain healthier bones. Discussion: Lactase intolerance has a strong relation with osteoporosis. On lactase intolerance management it is important to teach patients about non-lactose milk supplemented with calcium and vitamin D. Hormones and antiresortive medication should be restricted to specific cases with emphasis on climacteric patients that have osteoporosis with demonstrated hipercalciuria and increased urinary N-Telopeptides.


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