2002, Number 2
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ABSTRACTNeuroendocrino-immunology constitutes a new research field with a quick development that everytime wins more the interest between investigation groups and doctors because has been discovered an appreciable number of molecular phenomenon that they serve as base to explain multiple physiologic and pathological states whose mechanisms were ignored, for what was hindered to trace novel strategies for diagnoses and therapeutic goals. The description of the interactions among the nervous, endocrine and immune systems has allowed to understand the organic effects induced by the stress, physiologic and pathological events in the digestive tract, the physiopathology of the acute phase reactions, mechanism of multiple neurological illnesses, among other entities. The objective of this work is update some of the main integration ways between these three important systems and to discuss the new tendencies toward where go the investigations in this field.
Baraczka K, Nekam K, Pozsonyi T, Jakab L, Szongoth M, Sesztak M. Concentration of soluble adhesion molecules (sVCAM-1, sICAM-1 and sL-Selectin) in the cerebrospinal fluid and serum of patients with multiple sclerosis and systemic lupus erythematosus with central nervous involvement. Neuroimmunomodulation 2001; 9 (1): 49-54.
Pruett SB, Fan R, Myers P, Wu WS, Collier S. Quantitative analysis of the neuroendocrine-immune axis: linear modeling of the effects of exogenous corticosterone and restrain stress on lymphocyte subpopulations in the spleen and the thymus in female B6C3F1 mice. Brain Behavior Immunity 2000; 14: 270–287.