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Revista Cubana de Farmacia

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2014, Number 4

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Rev Cubana Farm 2014; 48 (4)

Evaluation of the measurement system analysis in the aluminum hydroxide gel production

Otero FMG, Mazorra LA, Ulloa EM
Full text How to cite this article

Language: Spanish
References: 9
Page: 533-541
PDF size: 294.90 Kb.


Key words:

measurement system, repeatability and reproducibility study, variability, repeatability, reproducibility, ANOVA.

ABSTRACT

Introduction: the repeatability and reproducibility study is based on experimental quantitation of the measurement system contribution to the total observed variability, and is aimed at determining whether this system is acceptable.
Objective: to evaluate the measurement system in aluminum hydroxide gel production process through the repeatability and reproducibility study.
Methods: this study was carried out through a balanced factorial experiment of random effect. Ten finished product samples from a production batch were measured twice by three randomly selected operators. The measurements were made in the Medilip research laboratory (Cross ANOVA method. Confidence level α= 0.05; 95 %). The statistical package Minitab 16 served to process relevant data.
Results: according to Cg and Cgk (type I Study) indexes, the measurement system was acceptable. The repeatability and reproducibility study determined that the main contributing factor was "parts" (98.85 %) and that the measurement system variability (3.15) was also allowable as well as the percentage of the study variance with regard to the total variance (17.75 %).
Conclusions: the repeatability and reproducibility study identifies the factor called "parts" as the one largely contributing to the total variability and determines that the measurement system is adequate, which is endorsed by international set standards, so it is recommended to take actions to improve its performance.


REFERENCES

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Rev Cubana Farm. 2014;48