Zavelia Padilla-Romo MG, Jaloma-Cruz AR

Language: Spanish
References: 5
Page: 399-402
PDF size: 221.03 Kb.

ABSTRACT

The diagnosis of von Willebrand disease (vWD) is complex and requires several screening and confirmation tests, such as the analysis of vWF multimers, which is considered the gold standard for vWD subtyping; however, it only discriminates 2A subtype while the 2B, 2M, and 2N subtypes require additional tests and even genetic testing for final confirmation. It is important to consider the patients’ hemotype for the vWD diagnosis, particularly in Mexico where hemotype “O” predominates and may entail a 20-25% decreased level of plasma vWF and increased bleeding tendency.

REFERENCES

1. Melo-Nava BM, Benitez H, Palacios JJ, Nieva B, Arenas D, Jaloma-Cruz AR, et al. Molecular study of VWF gene from Mexican Mestizo patients with von Willebrand disease, and the finding of three new mutations. Blood Cells Mol Dis. 2007;39(3):361-5.

2. Favaloro EJ. Diagnosis and classification of von Willebrand disease: a review of the differential utility of various functional von Willebrand factor assays. Blood Coagul Fibrinolysis. 2011;22(7):553-64.

3. Branchford BR, Di Paola J. Making a diagnosis of VWD. Hematology Am Soc Hematol Educ Program. 2012;2012:161-7.

4. Majluf-Cruz A, Velez-Ruelas MA, Gonzalez-Avila AI, et al. von Willebrand ´s disease in Mexico: a pilot study. Haemophilia. 2013;19(2): 231-5.

5. Morales-De la Vega A, Reyes-Maldonado E, Martínez-Murillo C, Quintana- González S. [Type 2N von Willebrand disease (Normandy)]. Rev Med Inst Mex Seguro Soc. 2008;46(1):55-62.